33486-90-7

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Synthesis Reference(s)

Synthetic Communications, 23, p. 749, 1993 DOI: 10.1080/00397919308009835

InChI:InChI=1/C8H8Cl2O/c1-11-5-6-7(9)3-2-4-8(6)10/h2-4H,5H2,1H3

Upstream product

• 67-56-1 methanol 
• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 4206-67-1 iodo(trimethylsilyl)methane 
• 15258-73-8 2,6-dichlorobenzyl alcohol 
• 124-41-4 sodium methylate 

Downstream Products

• 131980-46-6 2-methoxymethylbenzene-1,3-dicarbonitrile 
• 14920-87-7 2,6-dichlorobenzoic acid methyl ester 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 131980-48-8 2-methoxymethylbenzene-1,3-dimethanol 
• 131980-50-2 1,3-bis(bromomethyl)-2-methoxymethylbenzene 
• 131980-47-7 2-methoxymethylbenzene-1,3-dicarbaldehyde 

Relevant academic research and scientific papers

A convenient synthesis of methyl- and isopropyl-benzyl ethers using silver(II) oxide as reagent

Substituted bromomethyl- and chloromethylbenzenes and bis(bromomethyl) benzenes were directly converted, in high yields, to the corresponding methyl- and isopropyl-benzyl ethers by treatment with silver(II) oxide in methanol or isopropanol.

Synthesis of 9-Methoxymethyl-18-methyl-2,11-dithiametacyclophane: a Dithiametacyclophane with a Protected Internal Benzylic Functional Group

A synthetic route to a dithiametacyclophane with a benzylic functional (methoxymethyl) group at C9 is described.The benzylic function however had to be introduced at a later stage in the synthetic scheme to optimize the overall yield.Only the anti isomer of the desired dithiacyclophane (7) was isolated.The entire methoxymethyl group lies within the shielding zone of the opposite benzene ring as indicated in the 1H n.m.r. spectrum.Attempts to convert anti-(7) into the novel aromatic system (5b) by a rearrangement-elimination sequence however failed.

Unusual O-Alkylation with Iodomethyltrimethylsilane

Iodomethyltrimethylsilane alkylates alkoxide ions giving rise to O-methyl and O-trimethylsilyl ethers which are formed by cleavage of the silicon-carbon bond.

Mercury-assisted solvolyses of alkyl halides. Simple procedures for the preparation of nitrate esters, acetate esters, alcohols and ethers

The reactions of a wide variety of alkyl halides with mercury(I) and/or (II) nitrate in 1,2-dimethoxyethane, mercury(II) acetate in acetic acid, aqueous mercury(II) perchlorate, and mercury(II) perchlorate in alcohol solvents have been investigated; as a result, simple high yield procedures for the conversion of alkyl halides into the corresponding nitrate esters, acetate esters, alcohols and ethers have been developed.