33514-20-4

Upstream product

• 141-52-6 sodium ethanolate 
• 100-52-7 benzaldehyde 
• 589-92-4 1-methylcyclohexan-4-one 
• 64-17-5 ethanol 
• 62-53-3 aniline 
• 5601-45-6 4-(4-methylcyclohex-1-en-1-yl)morpholine 
• 7664-41-7 ammonia 
• 589-91-3 p-methylcyclohexanol 

Downstream Products

• 18013-02-0 5-Methyl-dihydropyrogallol 
• 1427056-62-9 5-benzylidene-3,3,7-trimethyl-9-phenyl-3,4,5,6,7,8-hexahydro-2H-xanthen-1(9H)-one 

Relevant academic research and scientific papers

Structure activity relationship analysis of antiproliferative cyclic C5-curcuminoids without DNA binding: Design, synthesis, lipophilicity and biological activity

The chemical susceptibility of the β-diketone linker between the two aromatic rings in the structure of curcumin to hydrolysis and metabolism has made it crucial to investigate structurally modified analogs of curcumin without such shortcomings. The synth

Base-catalyzed cross coupling of secondary alcohols and aryl-aldehydes with concomitant oxidation of alcohols to ketones: An alternative route for synthesis of the Claisen-Schmidt condensation products

Base-catalyzed C–C cross coupling of secondary alcohols and aryl-aldehydes was achieved, when an alcoholic solution of an aryl-aldehyde was stirred under reflux for 45?h in the presence of a catalytic (20?mol%) amount of K2CO3. The consistent formation of α,α′-bis-(benzylidene) alkanones was obtained in moderate to good yields using various secondary alcohols and substituted aryl-aldehydes. Herein, α,α′-bis-(benzylidene)alkanones, which are the classical products of Claisen-Schmidt (cross aldol) condensation, have been synthesized via an alternative strategy using secondary alcohols. Bis-(benzylidene) alkanones are an integral part of various drug regimes and the production of bis-(benzylidene) alkanones without using any precious metal is a major outcome of the present reaction.

Claisen-schmidt condensation catalyzed by metal-organic frameworks

Metal-organic framework [Fe(BTC) (BTC = 1,3,5-benzenetricarboxylic acid)] is a convenient heterogeneous catalyst for the carbon-carbon bond forming reaction in toluene between acetophenone and benzaldehyde to give selectively chalcone in high yield. Fe(BTC) appears as a general catalyst able to synthesize selectively different chalcone derivatives bearing various functionalities. Fe(BTC) could be recycled with no significant loss of catalytic efficiency and crystallinity in subsequent runs.

A RhCl(PPh3)3/BF3·OEt2 co-promoted direct C-C cross-coupling of alcohols at β-position with aldehydes

A novel RhCl(PPh3)3/BF3·OEt2 co-promoted direct C-C cross-coupling of primary and secondary alcohols at β-position with aldehyde was developed. This reaction could provide an efficient synthesis of a series of α

2-Heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(phenylmethylene)-2H-indazoles

Compounds of the formula STR1 wherein R, X1, X2, A and B are as defined herein, and their N-oxides and acid addition salts thereof, are provided which have been found to possess anti-inflammatory activity. In addition, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and methods for using such compositions as anti-inflammatory agents are also provided.

2-Aminoalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7(phenylmethylene)-2H-indazoles

Compounds of the following formula and their acid addition and quaternary salts and N-oxides SPC1 Wherein X is hydrogen, chloro, fluoro, trifluoromethyl, lower alkyl, or lower alkoxy, R is hydrogen or lower alkyl, A is alkylene of 1 to 8 carbons, and B is --NH2, EQU1 wherein R1 is lower alkyl and R2 is phenyl or phenyl-lower alkyl are disclosed. These compounds are useful as central nervous system depressants.