3352-06-5

Basic information

• Product Name: 1-Indolizinecarbonitrile, 3-phenyl-
• CAS NO: 3352-06-5
• Molecular Formula: C15H10N2
• Molecular Weight: 218.258
• Mol File: 3352-06-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-Indolizinecarbonitrile, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Indolizinecarbonitrile, 3-phenyl-(3352-06-5)
• EPA Substance Registry System: 1-Indolizinecarbonitrile, 3-phenyl-(3352-06-5)

Safety Data

• Hazardous Substances Data: 3352-06-5(Hazardous Substances Data)

Usage

Type of compound

heterocyclic aromatic compound

Structure

consists of an indolizine ring system and a carbonitrile functional group

Attachment position

carbonitrile group attached to the 3-phenyl position

Usage

building block in organic synthesis

Interest

potential biological activities in pharmaceutical and medicinal chemistry

Application

development of advanced materials

Utility

versatile and specific reagent in academic research

Upstream product

• 1126444-26-5 C₉H₅ClN₂ 
• 98-80-6 phenylboronic acid 
• 100-39-0 benzyl bromide 
• 110-86-1 pyridine 
• 2589-31-3 N-benzylpyridinium bromide 
• 107-13-1 acrylonitrile 
• 2739-97-1 pyridine-2-acetonitrile 
• 140-10-3 (E)-3-phenylacrylic acid 
• 3352-05-4 indolizine-1-carbonitrile 
• 80-17-1 benzenesufonyl hydrazide 
• 873-55-2 sodium benzenesulfonate 
• 98-09-9 benzenesulfonyl chloride 
• 100-42-5 styrene 
• 536-74-3 phenylacetylene 

Relevant articles and documents

An I2-catalyzed oxidative cyclization for the synthesis of indolizines from aromatic/aliphatic olefins and α-picoline derivatives

A novel I2-catalyzed intermolecular oxidative tandem cyclization reaction of aromatic/aliphatic olefins and α-picoline derivatives has been achieved for the synthesis of indolizines under metal-free conditions. In this transformation, substituted indolizines are obtained in moderate to good yields through C-C/C-N bond formation in one pot. This journal is

Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

A copper mediated radical oxidative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids is developed. This study offers a new and expedient strategy for the synthesis of useful indolizines in moderate to good yields and exhibits a broad substrate scope and good functional group tolerance.

Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides

An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1-methyl-2-pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C-3 arylation of indolizines. An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, the protocol using readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation proceeds in a mixed solvent of NMP and DME using simple triphenylphosphine a ligand, and provides a new method for the C-3 arylation of indolizines.