335216-97-2

Upstream product

• 108-30-5 succinic acid anhydride 
• 617-89-0 furan-2-ylmethanamine 

Downstream Products

• 908138-99-8 N-[3-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-prop-2-ynyl]-N'-furan-2-ylmethyl-succinamide 

Relevant academic research and scientific papers

Post-functionalization of an Anderson-type polyoxomolybdate using a metal-free Diels-Alder click reaction

Functionalization and post-functionalization of polyoxometalates (POMs) by organic groups or biological moieties can provide versatile platforms for creating novel functional hybrids with synergetic properties. Such materials can easily be envisioned as having many advanced applications in biology and materials science. Nowadays, the organic groups or biological moieties used for conjugation with POMs, can readily become increasingly complicated in terms of structure, size and properties. Accordingly, a major challenge lies in the development of efficient conjugation methods. In this work, we report our application of metal-free Diels-Alder click reactions under mild conditions to covalently link an Anderson-type polyoxomolybdate with some organic groups or biological moieties possessing complex structures or different properties. High coupling efficiencies and facile purification methods guarantee > 90 % yields. Clearly, this is an ideal methodology for the synthesis of the post-functionalized POM hybrids. With this technology now in hand, finding valuable applications for such post-functionalized POM hybrids will be a highly significant focus of future investigations. Copyright

Synthesis and Characterization of Dendrimer-Based Polysarcosine Star Polymers: Well-Defined, Versatile Platforms Designed for Drug-Delivery Applications

This paper describes the synthesis of star polymers designed for future drug-delivery applications. A generation-5 lysine dendrimer was used as a macroinitiator for the ring-opening polymerization of the sarcosine N-carboxyanhydride monomer to produce 32-arm star polymers with narrow molar mass distributions and desirable hydrodynamic size control. Fluorescent dye-labeled polymers were dosed in mice to measure plasma pharmacokinetics. Long circulation times were observed, representing ideal properties for biophysical targeting of tumors. In vivo efficacy of one of these star polymers conjugated to the therapeutic molecule SN-38 was evaluated in mice bearing SW620 xenografted tumors to demonstrate high antitumor activity and low body weight loss compared to the SN-38 prodrug irinotecan and this shows the potential of these delivery systems. As a further build, we demonstrated that these star polymers can be easily chain-end-functionalized with useful chemical moieties, giving opportunities for future receptor-targeting strategies. Finally, we describe the synthetic advantages of these star polymers that make them attractive from a pharmaceutical manufacturing perspective and report characterization of the polymers with a variety of techniques.

A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS

Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles.

Novel naphthalene-enoates: Design and anticancer activity through regulation cell autophagy

Eleven dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene derivatives as anticancer agents through regulating cell autophagy were designed and synthesized. The anticancer activity results indicated that most compounds manifested obvious un-toxic effec

MAGNETIC PARTICLE CONJUGATES, MICELLES, AND METHODS OF DELIVERING AGENTS

Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a magnetic composite nanocarrier (MCNC)), methods of making micelles, methods of using micelles, and the like.

SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES

The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.

Chemoselective acylation of amines in aqueous media

Amines are efficiently acylated by both cyclic and acyclic anhydrides by dissolving them in an aqueous medium with the help of a surfactant, sodium dodecyl sulfate (SDS). Cyclic and acyclic anhydrides react with equal ease with an amine, and amines with various stereo-electronic factors react at the same rates with an anhydride. Chemoselective acylation of amines in the presence of phenols and thiols and of thiols in the presence of phenols has been achieved. No acidic or basic reagents are used during the reaction. No Chromatographic separation is required for isolation of the acylated products. Reactions in a neutral aqueous medium, easy isolation of products, and innocuous by-products make the present method a green chemical process. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.