3360-70-1Relevant academic research and scientific papers
Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
Luo, Guanglin,Chen, Ling,Civiello, Rita,Pin, Sokhom S.,Xu, Cen,Kostich, Walter,Kelley, Michelle,Conway, Charles M.,MacOr, John E.,Dubowchik, Gene M.
scheme or table, p. 2917 - 2921 (2012/06/04)
In our continuing efforts to identify CGRP receptor antagonists that can be dosed orally for the treatment of migraine headache, we have investigated a pyridine bioisosteric replacement of a polar amide portion of a previous lead compound, BMS-694153. Pyr
4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR
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Page 24, (2008/06/13)
The invention relates to novel pyrazole derivatives which are inhibitors of the transforming growth factor, ("TGF")-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, m
An improved and practical procedure for the synthesis of substituted phenylacetylpyridines
Journet, Michel,Cai, Dongwei,Larsen, Robert D.,Reider, Paul J.
, p. 1717 - 1720 (2007/10/03)
A general procedure for the synthesis of substituted phenylacetylpyridines in excellent yields is described using a Horner-Emmons condensation between α-aminoalkylphosphonates of pyridinecarboxaldehydes and benzaldehydes with cesium carbonate at room temperature.
