3360-85-8Relevant academic research and scientific papers
Development of a Selective Inhibitor of Protein Arginine Deiminase 2
Muth, Aaron,Subramanian, Venkataraman,Beaumont, Edward,Nagar, Mitesh,Kerry, Philip,McEwan, Paul,Srinath, Hema,Clancy, Kathleen,Parelkar, Sangram,Thompson, Paul R.
supporting information, p. 3198 - 3211 (2017/04/19)
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the
Improved synthesis of functionalized mesogenic 2,6-bisbenzimidazolylpyridine ligands
McKenzie, Blayne M.,Miller, Adriane K.,Wojtecki, Rudy J.,Johnson, J. Casey,Burke, Kelly A.,Tzeng, Karis A.,Mather, Patrick T.,Rowan, Stuart J.
, p. 8488 - 8495 (2008/12/20)
A versatile one-pot synthetic platform for the preparation of a range of functionalized 2,6-bisbenzimidazolylpyridine (Bip) derivatives is presented. This protocol significantly reduces the cost and time of previous synthetic routes, while facilitating sc
Bent tridentate receptors in calamitic mesophases with predetermined photophysical properties: New luminescent lanthanide-containing materials
Nozary, Homayoun,Piguet, Claude,Tissot, Paul,Bernardinelli, Gérald,Bünzli, Jean-Claude G.,Deschenaux, Robert,Guillon, Daniel
, p. 12274 - 12288 (2007/10/03)
A new synthetic strategy has been developed to introduce bent and rigid tridentate 2,6-bis(benzimidazol-2'-yl)pyridine cores into rodlike ligands L(11-17). The crystal structure of the nonmesogenic ligand L13 (C39H37N5O4, triclinic, P1, Z = 2) shows the expected trans-trans conformation of the tridentate binding unit, which provides a linear arrangement of the semirigid aromatic sidearms. The crystal structure of the related mesogenic ligand L16 (C61H81N5O4, triclinic, P1, Z = 2) demonstrates the fully extended conformation adopted by the lipophilic side chains, leading to a slightly helically twisted I-shaped molecule. A rich and varied mesomorphism results which can be combined with the simultaneous tuning of electronic and photophysical properties via a judicious choice of the spacers between the rigid central core and the semirigid lipophilic sidearms. Ligands L13,14 react with Ln(NO3)3·χH2O to give quantitatively and selectively the neutral 1:1 complexes [Ln(L')(NO3)3] (Ln = La to Lu), which are stable in the solid state at room temperature but partially dissociate in acetonitrile to give the cationic species [Ln(L')(NO3)2]+. The crystal structure of [Lu-(L13)(NO3)3]·3CH3CN (30, LUC45H46N11O13, monoclinic, C2/c, Z = 8) reveals a U-shaped arrangement of the ligand strand arising from the cis-cis conformation of the coordinated tridentate binding unit. This drastic geometric change strongly affects the thermal behavior and the photophysical and electronic properties of the lipophilic complexes [Ln(L14)(NO3)3]. Particular attention has been focused on structure-properties relationships, which can be modulated by the size of the lanthanide metal ions.
Toward lanthanide-containing metallomesogens with tridentate ligands
Nozary, Homayoun,Piguet, Claude,Tissot, Paul,Bernardinelli, Gerald,Deschenaux, Robert,Vilches, Maria-Teresa
, p. 2101 - 2102 (2007/10/03)
Tridentate aromatic receptors L1-L4 containing the 2,6-bis-(benzimidazol-2-yl)pyridine chelating unit are designed to exhibit thermotropic calamitic liquid-crystalline phases; the mesomorphic behaviour is essentially retained in the
