79938-45-7Relevant academic research and scientific papers
Development of a Selective Inhibitor of Protein Arginine Deiminase 2
Muth, Aaron,Subramanian, Venkataraman,Beaumont, Edward,Nagar, Mitesh,Kerry, Philip,McEwan, Paul,Srinath, Hema,Clancy, Kathleen,Parelkar, Sangram,Thompson, Paul R.
, p. 3198 - 3211 (2017)
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the
INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF
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Paragraph 00144; 00145; 00148, (2018/06/22)
The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.
