33620-66-5Relevant academic research and scientific papers
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor
Nakao, Syuhei,Mabuchi, Miyuki,Wang, Shenglan,Kogure, Yoko,Shimizu, Tadashi,Noguchi, Koichi,Tanaka, Akito,Dai, Yi
supporting information, p. 3167 - 3172 (2017/06/13)
A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC). Compound 4z (HUHS029) exhibited higher inhibitory activity than resveratrol with an IC50 value of 16.1?μM. The activity of 4z on TRPA1 was confirmed in TRPA1-expressing HEK293 cells, as well as in rat dorsal root ganglia neurons by a whole cell patch clamp recording. Furthermore, pretreatment with 4z exhibited an analgesic effect on AITC-evoked TRPA1-related pain behavior in vivo.
SYNTHESE DE CETONES SPIRANNIQUES TRICYCLIQUES DERIVEES DE PRODUITS NATURELS
Berrier, Christian,Jacquesy, Jean-Claude,Renoux, Alain
, p. 212 - 218 (2007/10/02)
In SbF5-HF compound 10a is unreactive whereas esters 10b and 10c cyclize to enones 18 (b or c) and 19 (b or c).Protonation of the esters groups prevents the corresponding aromatic ring protonation and deactivation which is observed with phenol 10a.Spiroke
Spasmolytic Principle from Rheum webbianum Royle
Chaudhar, M.,Jain, G. K.,Sarin, J. P.,Khanna, N. M.
, p. 1163 - 1164 (2007/10/02)
The structure of spasmolytic principle, isolated from Rheum webbianum, has ben established as 3',5'-dihydroxy-4-methoxystilbene on the basis of physico-chemical studies.
