33642-96-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 172487-18-2 ethyl Phenylphosphinate 
• 57483-31-5 ethyl (1?hydroxy?1?methylethyl)phenylphosphinate 
• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 15453-04-0 (1-Hydroxy-1-methylethyl)-diphenylphosphine oxide 
• 4559-70-0 Diphenylphosphine oxide 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 

Downstream Products

• 63509-23-9 (R)-((R)-2-Nitro-1-phenyl-ethyl)-phenyl-phosphinic acid ethyl ester 
• 63509-23-9 (R)-((S)-2-Nitro-1-phenyl-ethyl)-phenyl-phosphinic acid ethyl ester 
• 128640-27-7 (R)-((R)-1-Benzo[1,3]dioxol-5-yl-2-nitro-ethyl)-phenyl-phosphinic acid ethyl ester 
• 128640-27-7 (R)-((S)-1-Benzo[1,3]dioxol-5-yl-2-nitro-ethyl)-phenyl-phosphinic acid ethyl ester 
• 128640-11-9 (R)-[(R)-1-(4-Methoxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-11-9 (R)-[(S)-1-(4-Methoxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-21-1 (R)-[(R)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-21-1 (R)-[(S)-1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-18-6 (R)-[(R)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 128640-18-6 (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid ethyl ester 
• 84434-11-7 2,4,6-trimethylbenzoylphenylphosphinic acid ethyl ester 
• 131149-08-1 ethyl <(4-acetamidophenyl)aminomethane>phenylphosphinate 
• 131149-00-3 ethyl <(4-acetamidophenyl)allylaminomethane>phenylphosphinate 
• 128640-14-2 (R)-[(R)-2-Nitro-1-(3-phenoxy-phenyl)-ethyl]-phenyl-phosphinic acid ethyl ester 

Relevant academic research and scientific papers

An efficient synthesis of cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of pipecolic acid from cyclic enaminones

An expedient synthetic entry to cis-4-hydroxyphosphonic and cis-4-hydroxyphosphinic analogs of cis-4-hydroxypipecolic acid is presented in this paper. The main feature of this methodology is the highly regioselective addition of silyl phosphites or phosph

Chlorosilane-Catalyzed Coupling of Hydrogen Phosphine Oxides with Acyl Chlorides Generating Acylphosphine Oxides

We report a new method for the synthesis of acylphosphine oxides by the direct coupling of hydrogen phosphine oxides and acyl chlorides mediated by chlorosilanes. This new protocol is greener and safer, because it precludes the generation of volatile haloalkanes and the use of oxidants employed in the conventional methods. Moreover, moisture-unstable acylphosphine oxides that are difficult to prepare via the conventional methods can be generated using this new method.

New synthesis of trimethylsilyl esters of phosphorus(III) acids

Abstract: A novel synthetically important reaction has been developed for the quick, convenient, and high-yield preparation of trimethylsilyl esters of phosphorus(III) acids, synthetically valuable Michaelis–Arbuzov reaction precursors. Commercially and synthetically available initial compounds used are derivatives of propan-2-ol phosphorylated in the second position capable of long-term storage and available silylating reagents: hexamethyldisilazane, bis(trimethylsilyl)acetamide, and diethyl(trimethylsilyl)amine. Also, a stepwise reaction scheme of the starting compounds with silylating reagents has been proposed. Graphic abstract: [Figure not available: see fulltext.].

SYNTHESIS AND STEREOCHEMISTRY OF α-ARYL-β-NITROALKYLPHOSPHINATES

An one-pot reaction of O-alkyl arylphosphonites 1 with α-aryl-β-nitroalkenes (β-nitrostyrenes) 2 in the presence of trimethylsilylchloride and triethylamine was studied.Twenty-three new α-aryl-β-nitroalkylphosphinates 3a-y were synthesized in high yield u