3367-54-2

Basic information

• Product Name: 1,4-bis(4-chlorophenyl)piperazine
• CAS NO: 3367-54-2
• Molecular Formula: C₁₆H₁₆Cl₂N₂
• Molecular Weight: 307.2176
• Mol File: 3367-54-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 467.8°C at 760 mmHg
• Flash Point: 236.7°C
• Density: 1.275g/cm³
• Vapor Pressure: 6.33E-09mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 1,4-bis(4-chlorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis(4-chlorophenyl)piperazine(3367-54-2)
• EPA Substance Registry System: 1,4-bis(4-chlorophenyl)piperazine(3367-54-2)

Safety Data

• Hazardous Substances Data: 3367-54-2(Hazardous Substances Data)

Usage

General Description

1,4-bis(4-chlorophenyl)piperazine, also known as TFMPP, is a chemical compound commonly used as a recreational drug due to its psychoactive effects. It belongs to the class of piperazine derivatives and is structurally related to mCPP (meta-Chlorophenylpiperazine). TFMPP acts as a serotonin receptor agonist, specifically targeting the 5-HT2 receptor, which is involved in the regulation of mood, anxiety, and cognition. It is often used in combination with other substances, such as BZP (benzylpiperazine), to enhance its psychoactive effects. TFMPP has been banned in several countries due to its potential for misuse and associated health risks.

Upstream product

• 110-85-0 piperazine 
• 106-46-7 para-dichlorobenzene 
• 106-39-8 bromochlorobenzene 
• 127-09-3 sodium acetate 
• 106-47-8 4-chloro-aniline 
• 106-93-4 ethylene dibromide 

Downstream Products

• 854246-54-1 N,N'-bis-(4-chloro-2,6-dinitro-phenyl)-N,N'-dinitro-ethylenediamine 
• 74853-08-0 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine 

Relevant articles and documents

Piperazine derivative and organic photoelectric device comprising same

The invention provides a piperazine derivative, an organic photoelectric device containing the same, and a piperazine derivative for improving the light-emitting utilization and-color purity of the organic light-emitting device. The organic light emitting device of the cover layer material provided by the invention can realize high light emission efficiency and color purity, and the organic light emitting element can be used for an organic EL display. A light source such as lighting, a marking plate, an identification lamp and the like. The invention provides an organic light emitting device which greatly improves the light emitting utilization rate and has excellent color purity. The present invention is characterized by the following general formula (1). Specific chemical structures and device performance are described in detail in the specification.

Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.