3367-54-2

Usage

Uses

Used in Recreational Drug Industry:
TFMPP is used as a psychoactive substance for its mood-altering and cognitive effects. It is often combined with other substances, such as BZP (benzylpiperazine), to enhance its recreational effects. However, its use is restricted due to the potential for misuse and associated health risks.
Used in Research Applications:
TFMPP serves as a valuable research tool in the study of serotonin receptor function and the development of new therapeutic agents targeting the 5-HT2 receptor. Its selective agonist activity allows researchers to investigate the role of this receptor in various physiological and pathological processes.
Used in Drug Development:
Due to its interaction with the 5-HT2 receptor, TFMPP has potential applications in the development of new drugs for the treatment of mood disorders, anxiety, and cognitive impairments. Its structural features can be used as a starting point for the design of novel compounds with improved efficacy and safety profiles.

Upstream product

• 127-09-3 sodium acetate 
• 106-47-8 4-chloro-aniline 
• 106-93-4 ethylene dibromide 
• 110-85-0 piperazine 
• 106-46-7 para-dichlorobenzene 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 854246-54-1 N,N'-bis-(4-chloro-2,6-dinitro-phenyl)-N,N'-dinitro-ethylenediamine 
• 74853-08-0 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine 

Relevant academic research and scientific papers

Piperazine derivative and organic photoelectric device comprising same

The invention provides a piperazine derivative, an organic photoelectric device containing the same, and a piperazine derivative for improving the light-emitting utilization and-color purity of the organic light-emitting device. The organic light emitting device of the cover layer material provided by the invention can realize high light emission efficiency and color purity, and the organic light emitting element can be used for an organic EL display. A light source such as lighting, a marking plate, an identification lamp and the like. The invention provides an organic light emitting device which greatly improves the light emitting utilization rate and has excellent color purity. The present invention is characterized by the following general formula (1). Specific chemical structures and device performance are described in detail in the specification.

Preparation method of posaconazole intermediate 1-(4-aminophenyl)-4-(4-hydroxylphenyl)piperazine

The invention discloses a preparation method of a posaconazole intermediate, namely 1-(4-aminophenyl)-4-(4-hydroxylphenyl)piperazine, belonging to the field of medicinal chemistry. The preparation method comprises the following steps: S1, with chlorobromobenzene and anhydrous piperazine as raw materials, generating 1,4-bis(4-chlorophenyl)piperazine under certain conditions; S2, performing single-side methylation on the product generated in the step S1 to obtain 1-(4-methoxyphenyl)-4-(4-chlorophenyl)piperazine; S3, performing ammoniation on the product in the step S2 to obtain 1-(4-methoxyphenyl)-4-(4-aminophenyl)piperazine; and S4, demethylating the product obtained in the step S3, and carrying out crystallizing and purifying to obtain the 1-(4-aminophenyl)-4-(4-hydroxylphenyl)piperazine.The raw materials used in the preparation method are very cheap; reaction conditions are relatively simple; the method is easy to implement; yield is high; and the cost of a final product can be obviously reduced.

Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.