337-16-6

Basic information

• Product Name: Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester
• Synonyms: Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate
• CAS NO: 337-16-6
• Molecular Formula: C₅H₇F₃O₃
• Molecular Weight: 172.1024896
• EINECS: -0
• Mol File: 337-16-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester(337-16-6)
• EPA Substance Registry System: Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester(337-16-6)

Safety Data

• Hazardous Substances Data: 337-16-6(Hazardous Substances Data)

Upstream product

• 13089-11-7 methyl 3,3,3-trifluoropyruvate 
• 506-82-1 dimethylcadmium 
• 374-35-6 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 

Downstream Products

• 374-35-6 (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 
• 24435-45-8 (S)-2-trifluoromethyllactic acid 
• 1262859-33-5 rac-methyl 2-(2-(3-bromophenyl)-2-oxoethoxy)-3,3,3-trifluoro-2-methylpropanoate 
• 374-35-6 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 
• 60200-80-8 ethyl 2-phenoxy-3,3,3-trifluoro-2-trifluoromethylpropionate 
• 93496-97-0 2-[4-(4-Chloro-benzoyl)-benzyloxy]-3,3,3-trifluoro-2-methyl-propionic acid methyl ester 
• 93496-93-6 3,3,3-Trifluoro-2-methyl-2-(4-phenoxy-benzyloxy)-propionic acid methyl ester 
• 60201-23-2 (+/-)-methyl 2-(4-phenoxyphenoxy)-3,3,3-trifluoro-2-methylpropionate 
• 60201-02-7 (+/-)-methyl 2-(4-chlorophenoxy)-3,3,3-trifluoro-2-methylpropionate 
• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 

Relevant articles and documents

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profile wi

The synthesis of (R)- and (S)-α-trifluoromethyl-α-hydroxycarboxylic acids via enzymatic resolutions

Kinetic resolution of 1, 1, 1-trifluoro-2-alkanone cyanohydrin acyl derivatives with Candida rugosa lipase afforded the remaining (R)-enantiomer in high selectivity (E from 30 to >200). Candida rugosa lipases from several suppliers were compared and found