Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate

Base Information

Chemical Name:Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate
CAS No.:337-16-6
Molecular Formula:C5H7F3O3
Molecular Weight:172.104
Hs Code.:
European Community (EC) Number:873-949-9
DSSTox Substance ID:DTXSID60538990
Nikkaji Number:J1.586.288B
Mol file:337-16-6.mol

Synonyms:Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate;337-16-6;SCHEMBL361851;DTXSID60538990;AKOS026736785;CS-0227555;EN300-1167097;(+/-)-methyl 2-hydroxy-2-trifluoromethylpropionate;Methyl(S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoate;3,3,3-trifluoro-2-hydroxy-2-methyl-propionic acid methyl ester

Suppliers and Price of Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate

Chemical Property:

PSA：46.53000
LogP:0.47270
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:172.03472857
Heavy Atom Count:11
Complexity:165

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)OC)(C(F)(F)F)O

Technology Process of Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate

There total 4 articles about Methyl 3,3,3-trifluoro-2-hydroxy-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 374-35-6
3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

: 149-73-5
trimethyl orthoformate

: 337-16-6
2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester

Guidance literature:: With sulfuric acid; In methanol; for 20h; Reflux; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02143

Reference yield: 73.5%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 506-82-1
dimethylcadmium

: 337-16-6
2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester

Guidance literature:: In diethyl ether; 1) 20 deg C, 1 h, 2) reflux, 0.5 h;

Reference yield:

: 67-56-1
methanol

: 374-35-6
3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

: 337-16-6
2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo400115r