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337496-05-6

6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 337496-05-6 Structure

  • Basic information

    1. Product Name: 6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID
    2. Synonyms: BAS 01316951;IVK/1267163;Oprea1_084539;Oprea1_658482;6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID;6,8-dimethyl-2-phenyl-4-quinolinecarboxylic acid;6,8-dimethyl-2-phenyl-cinchoninic acid
    3. CAS NO:337496-05-6
    4. Molecular Formula: C18H15NO2
    5. Molecular Weight: 277.3172
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 337496-05-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID(337496-05-6)
    11. EPA Substance Registry System: 6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID(337496-05-6)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 337496-05-6(Hazardous Substances Data)

337496-05-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 337496-05-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,7,4,9 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 337496-05:
(8*3)+(7*3)+(6*7)+(5*4)+(4*9)+(3*6)+(2*0)+(1*5)=166
166 % 10 = 6
So 337496-05-6 is a valid CAS Registry Number.

337496-05-6Downstream Products

337496-05-6Relevant articles and documents

Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation

Liu, Wei,Jia, Hairui,Guan, Minghao,Cui, Minxuan,Lan, Zhuxuan,He, Youyou,Guo, Zhongjie,Jiang, Ru,Dong, Guoqiang,Wang, Shengzheng

, (2021/11/22)

The colchicine binding site of tubulin is a promising target for discovering novel antitumor agents which exert the antiangiogenic effect and are not susceptible to multidrug resistance. For identifying novel tubulin inhibitors, structure-based virtual screening was applied to identify hit 9 which displayed moderate tubulin polymerization inhibition and broad-spectrum in vitro antitumor activity. Structural optimization was performed, and biological assay revealed analog E27 displayed the best antitumor activity with IC50 values ranging from 7.81 μM to 10.36 μM, and improved tubulin polymerization inhibitory activity (IC50 = 16.1 μM). It significantly inhibited cancer cell migration and invasion, induced cell apoptosis and arrested the cell cycle at G2/M phase. Moreover, the apoptotic effect of E27 is related to the increased ROS level, the decrease of MMP, and the abnormal expression of apoptosis-related proteins. Taken together, these results suggested E27 was a promising lead compound for discovering novel tubulin-targeted antitumor agents.

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