3375-25-5

Upstream product

• 509-34-2 rhodamine B 
• 1206830-39-8 rhodamine B selenolactone 
• 1256843-84-1 C₃₅H₃₈N₄O₄S 
• 1195931-66-8 3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl bis(trifluoromethanesulfonate) 
• 109-89-7 diethylamine 
• 2321-07-5 fluorescein 
• 1115867-62-3 rhodamine hydroxamic acid 

Downstream Products

• 117940-31-5 (trimethylsilyl)rhodamine trifluoromethanesulfonate 
• 509-34-2 rhodamine B 
• 617-84-5 N-formyldiethylamine 
• 55-18-5 N-Nitrosodiethylamine 
• 124-38-9 carbon dioxide 
• 109-89-7 diethylamine 
• 770686-36-7 N-(9-(2-(chlorocarbonyl)phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)-N-ethylethanaminium 
• 74317-53-6 rhodamine B hydrazide 
• 1270954-12-5 CH₃O^(1-)*C₃₀H₃₅N₂O₂S⁽¹⁺⁾ 
• 1233527-69-9 C₂₉H₃₀N₂O₂ 
• 1270954-10-3 CH₃O^(1-)*C₃₀H₃₅N₂O₃⁽¹⁺⁾ 

Relevant academic research and scientific papers

Dual signaling of thallium(III) ions via oxidative cleavage of a sulfonhydrazide linkage

The thallium is widely used in various research and industrial applications but is very toxic. In this work, we developed a novel reaction-based dual signaling probe for the selective and sensitive determination of Tl3+ via the oxidative cleavage of a rhodamine–dansylhydrazide conjugate. The designed probe showed pronounced colorimetric and fluorescence signaling behavior toward Tl3+ with a detection limit of 1.3 × 10–7 M (0.027 ppm), as well as selectivity over other common metal ions, anions, and oxidants. The Tl3+ signaling process required less than 2 min and was not influenced by the solution pH within the range of 4.0–5.5; however, the signal diminished significantly above pH 6.0. To demonstrate the practical applicability of the designed probe, a simple and convenient colorimetric assay for the determination of Tl3+ in commercial reagents was established using an office scanner as a readily available signal capturing device.

A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents

A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.

Activation of fluorescence of lactone forms of rhodamine dyes by photodehydrogenation of aryl(hetaryl)pyrazolines

Aryl(hetaryl)pyrazolines are effective photogenerators of acid providing an irreversible photochemical activation of fluorescence of rhodamine group dyes. The effect of solvent on two consecutive reactions, photodehydrogenation of pyrazoline and lactone ring opening of the dye was studied. An increase in solvent polarity leads to an increase in the rate of both reactions by different degrees. The systems under study are believed to be promising for the formation of recording media for multilayer optical file type disks of ultrahigh data storage capacity with fluorescent readout.

Ratiometric Signaling of Hypochlorite by the Oxidative Cleavage of Sulfonhydrazide-Based Rhodamine-Dansyl Dyad

(Figure Presented). A reaction-based probe 1 for hypochlorite signaling was designed by the conjugation of two fluorophores, rhodamine and dansyl moieties, by the reaction of rhodamine B base with dansylhydrazine. Probe 1 exhibited pronounced hypochlorite-selective chromogenic and fluorescent signaling behavior over other oxidants used in practical applications, such as hydrogen peroxide, peracetic acid, and ammonium persulfate, as well as commonly encountered metal ions and anions. Signaling was attributed to the hypochlorite-induced oxidative cleavage of the sulfonhydrazide linkage of the probe. In particular, favorable ratiometric fluorescence signaling was possible by utilizing the emissions of the two fluorophores. A detection limit of 1.13 × 10-6 M (0.058 ppm) was estimated for the determination of hypochlorite. A paper-based test strip was prepared and was used as a semiquantitative indicator for the presence of hypochlorite in aqueous solutions. The probe was also successfully applied for the determination of hypochlorite in practical tap water samples.

Sulfonyl rhodamine hydrazide: A sensitive and selective chromogenic and fluorescent chemodosimeter for copper ion in aqueous media

A novel, sulfonyl rhodamine hydrazide chemodosimeter displayed highly selective and sensitive recognition of Cu2+ in aqueous media, via colour change from colorless to pink. The colour change that occurred as a result of complexation with Cu2+ can be attributed to spirolactam ring-opening and hydrolysis of the hydrazide unit to afford C.I. Acid Red 52 (Rhodamine B) in the presence of Cu2+. An analytical method was developed and successfully used for the determination of the copper content in a sample.

Synthesis of rhodamines from fluoresceins using pd-catalyzed c-n cross-coupling

A unified, convenient, and efficient strategy for the preparation of rhodamines and N,N′-diacylated rhodamines has been developed. Fluorescein ditriflates were found to undergo palladium-catalyzed C-N cross-coupling with amines, amides, carbamates, and other nitrogen nucleophiles to provide direct access to known and novel rhodamine derivatives, including fluorescent dyes, quenchers, and latent fluorophores.

An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based on its reaction with a selenide

A new strategy that utilizes the interaction between NO and a selenide is reported for fluorescence detection of NO, in which rhodamine B selenolactone serves as a model selenide. The Royal Society of Chemistry 2011.

A selenolactone-based fluorescent chemodosimeter to monitor mecury/methylmercury species in vitro and in vivo

A fluorescent probe based on selenolactone displays unique fluorescence enhancement and UV-vis spectral change for mercury/methylmercury species, which were attributed to deselenation reaction. The value of this system was successfully demonstrated by its use in detecting inorganic mercury/methylmercury species in cells and zebrafish.

Imaging different interactions of mercury and silver with live cells by a designed fluorescence probe rhodamine b selenolactone

Rhodamine B selenolactone has been designed, synthesized, and characterized as a new fluorescent probe for imaging both Hg2+ and Ag+ in live cells to better understand their distinct toxicities to organisms. The probe is designed based on the fact that selenium has a strong affinity for mercury and silver, and is constructed by incorporating a Se atom into the spirocyclic structure of rhodamine. It exhibits a rapid and specific spectroscopic off-on response to Hg2+ and Ag+ instead of other species, with detection limits of 23 nM Hg2+ and 52 nM Ag +. Moreover, the probe is membrane-permeable, and can react with Ag+ even in the presence of Cl- because of the higher affinity of Se than Cl- for Ag+, which makes it of potential use for imaging not only Hg2+ but also Ag+ in live cells. This applicability has been demonstrated by imaging Hg2+ and Ag+ in Hela cells. It is observed that the reaction of Ag + with the probe inside the cells occurs much slower than that of Hg2+, which is ascribed to the high concentration of cellular chloride ions inhibiting the formation of sufficient free Ag+. The present finding is helpful to get an insight into the different interaction mechanism of Hg2+ and Ag+ with cells, and more applications of the probe may be expected for studying the behaviors of Hg 2+ and Ag+ in various biosystems.

Ionization and Tautomerism of Hydroxyxanthenes and Some Other Dyes in Ethanol

Protolytic equilibria of hydroxyxanthene dyes, Fluorescein and Eosin, as well as of some related compounds, in ethanol were studied by spectrophotometry. Stepwise ionization and tautomeric equilibrium constants were determined.