337508-64-2

Basic information

• Product Name: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE
• Synonyms: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE;4-Oxazolecarbonyl chloride, 5-phenyl- (9CI);5-Phenyl-1,3-oxazole-4-carbonyl chloride ,97%;5-Phenyloxazole-4-carbonyl chloride;4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole
• CAS NO: 337508-64-2
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.61
• Product Categories: ACIDHALIDE
• Mol File: 337508-64-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 74 °C
• Boiling Point: 357.187 °C at 760 mmHg
• Flash Point: 169.821 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(337508-64-2)
• EPA Substance Registry System: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(337508-64-2)

Safety Data

• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 337508-64-2(Hazardous Substances Data)

Usage

General Description

5-Phenyl-1,3-oxazole-4-carbonyl chloride is a chemical compound with the molecular formula C11H6ClNO2. It belongs to the group of phenyl oxazoles which are organic compounds containing an oxazole ring substituted with a phenyl group. It is a relatively complex organic compound and is often used in chemical synthesis processes where particular types of reactions and properties are required. 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE often appears as a light-colored solid and should be handled with standard safety precautions due to its reactive chloro-carbonyl group. Further detailed information including its physical and chemical properties, reactivity, toxicity, storage requirements, and safety measures should be conducted according to the safety data sheet provided by the manufacturer or supplier.

InChI:InChI=1/C10H6ClNO2/c11-10(13)8-9(14-6-12-8)7-4-2-1-3-5-7/h1-6H

Upstream product

• 32998-97-3 ethyl 5-phenyl-1,3-oxazole-4-carboxylate 
• 99924-18-2 5-phenyl-1,3-oxazole-4-carboxylic acid 

Downstream Products

• 1252656-07-7 [4-(2-tert-butylphenyl)piperazin-1-yl](5-phenyloxazol-4-yl)methanone 
• 1026875-69-3 4,4-dimethyl-5'-phenyl-2'-(1-trimethylsilanyloxy-nonyl)-4,5-dihydro-[2,4']bioxazolyl 
• 1028266-44-5 4,4-dimethyl-5'-phenyl-2'-(1-trimethylsilanyloxy-cyclohexyl)-4,5-dihydro-[2,4']bioxazolyl 
• 438553-17-4 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-nonan-1-ol 
• 1026335-08-9 5-phenyl-2-(1-trimethylsilanyloxy-nonyl)-oxazole-4-carbaldehyde 
• 1026936-09-3 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl 
• 438553-18-5 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-cyclohexanol 
• 438553-16-3 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol 
• 438553-19-6 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-3-methylbutan-1-ol 
• 1027834-63-4 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde 

Relevant articles and documents

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.

The synthesis of an array of 5-phenyloxazole derivatives bearing a variety of hydroxyalkyl groups at the C-2 position of the heterocyclic nucleus and possessing a formyl or a carboxyl function at C-4 is reported. These bifunctionalized compounds have been efficiently prepared by addition of carbonylated electrophiles to the 2-lithio derivative of 5-phenyloxazole preliminarily equipped with an oxazoline unit at the 4-position of the oxazole nucleus. It is demonstrated that this protocol offers a double advantage since it suppresses the troublesome electrocyclic ring-opening reaction and allows access to the target compounds by simple chemical transformation of the oxazoline ring system.