337508-64-2

Basic information

• Product Name: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE
• Synonyms: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE;4-Oxazolecarbonyl chloride, 5-phenyl- (9CI);5-Phenyl-1,3-oxazole-4-carbonyl chloride ,97%;5-Phenyloxazole-4-carbonyl chloride;4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole
• CAS NO: 337508-64-2
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.61
• Product Categories: ACIDHALIDE
• Mol File: 337508-64-2.mol

Chemical Properties

• Melting Point: 74 °C
• Boiling Point: 357.187 °C at 760 mmHg
• Flash Point: 169.821 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(337508-64-2)
• EPA Substance Registry System: 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE(337508-64-2)

Safety Data

• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 337508-64-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
5-Phenyl-1,3-oxazole-4-carbonyl chloride is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable building block for the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Phenyl-1,3-oxazole-4-carbonyl chloride is used as a starting material for the development of new drugs. Its versatile chemical properties allow for the formation of a wide range of drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
5-Phenyl-1,3-oxazole-4-carbonyl chloride is also used in the agrochemical industry as a precursor for the synthesis of new pesticides and other crop protection agents. Its ability to form complex molecules makes it a valuable component in the development of innovative agrochemical products.
Used in Specialty Chemicals:
In the specialty chemicals sector, 5-Phenyl-1,3-oxazole-4-carbonyl chloride is used as a component in the production of various high-value chemicals. Its unique properties contribute to the development of advanced materials with specific applications in industries such as electronics, coatings, and adhesives.

InChI:InChI=1/C10H6ClNO2/c11-10(13)8-9(14-6-12-8)7-4-2-1-3-5-7/h1-6H

Upstream product

• 99924-18-2 5-phenyl-1,3-oxazole-4-carboxylic acid 
• 32998-97-3 ethyl 5-phenyl-1,3-oxazole-4-carboxylate 

Downstream Products

• 438553-15-2 4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazole 
• 1026130-52-8 2-(3-methyl-1-trimethylsilanyloxy-butyl)-5-phenyl-oxazole-4-carbaldehyde 
• 1027834-63-4 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde 
• 438553-19-6 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-3-methylbutan-1-ol 
• 438553-16-3 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol 
• 438553-18-5 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-cyclohexanol 
• 1026936-09-3 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl 
• 1026335-08-9 5-phenyl-2-(1-trimethylsilanyloxy-nonyl)-oxazole-4-carbaldehyde 
• 438553-17-4 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-nonan-1-ol 

Relevant articles and documents

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.

The synthesis of an array of 5-phenyloxazole derivatives bearing a variety of hydroxyalkyl groups at the C-2 position of the heterocyclic nucleus and possessing a formyl or a carboxyl function at C-4 is reported. These bifunctionalized compounds have been efficiently prepared by addition of carbonylated electrophiles to the 2-lithio derivative of 5-phenyloxazole preliminarily equipped with an oxazoline unit at the 4-position of the oxazole nucleus. It is demonstrated that this protocol offers a double advantage since it suppresses the troublesome electrocyclic ring-opening reaction and allows access to the target compounds by simple chemical transformation of the oxazoline ring system.