1027834-63-4

Basic information

• Product Name: 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde
• Synonyms: 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde
• CAS NO: 1027834-63-4
• Molecular Weight: 351.477
• Mol File: 1027834-63-4.mol

Chemical Properties

• CAS DataBase Reference: 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde(1027834-63-4)
• EPA Substance Registry System: 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde(1027834-63-4)

Safety Data

• Hazardous Substances Data: 1027834-63-4(Hazardous Substances Data)

Upstream product

• 438553-16-3 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol 
• 438553-15-2 4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazole 
• 337508-64-2 5-phenyl-1,3-oxazole-4-carbonyl chloride 
• 99924-18-2 5-phenyl-1,3-oxazole-4-carboxylic acid 
• 32998-97-3 ethyl 5-phenyl-1,3-oxazole-4-carboxylate 
• 100-52-7 benzaldehyde 
• 1026936-09-3 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl 

Relevant articles and documents

Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.

The synthesis of an array of 5-phenyloxazole derivatives bearing a variety of hydroxyalkyl groups at the C-2 position of the heterocyclic nucleus and possessing a formyl or a carboxyl function at C-4 is reported. These bifunctionalized compounds have been efficiently prepared by addition of carbonylated electrophiles to the 2-lithio derivative of 5-phenyloxazole preliminarily equipped with an oxazoline unit at the 4-position of the oxazole nucleus. It is demonstrated that this protocol offers a double advantage since it suppresses the troublesome electrocyclic ring-opening reaction and allows access to the target compounds by simple chemical transformation of the oxazoline ring system.