438553-16-3

Basic information

• Product Name: 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol
• Synonyms: 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol
• CAS NO: 438553-16-3
• Molecular Weight: 348.401
• Mol File: 438553-16-3.mol

Chemical Properties

• CAS DataBase Reference: 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol(438553-16-3)
• EPA Substance Registry System: 1-[4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazol-2-yl]-1-phenylmethanol(438553-16-3)

Safety Data

• Hazardous Substances Data: 438553-16-3(Hazardous Substances Data)

Upstream product

• 337508-64-2 5-phenyl-1,3-oxazole-4-carbonyl chloride 
• 99924-18-2 5-phenyl-1,3-oxazole-4-carboxylic acid 
• 32998-97-3 ethyl 5-phenyl-1,3-oxazole-4-carboxylate 
• 100-52-7 benzaldehyde 
• 438553-15-2 4-(4,4-dimethyloxazolin-2-yl)-5-phenyloxazole 

Downstream Products

• 1027834-63-4 5-phenyl-2-(phenyl-trimethylsilanyloxy-methyl)-oxazole-4-carbaldehyde 
• 1026936-09-3 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl 

Relevant articles and documents

Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.

The synthesis of an array of 5-phenyloxazole derivatives bearing a variety of hydroxyalkyl groups at the C-2 position of the heterocyclic nucleus and possessing a formyl or a carboxyl function at C-4 is reported. These bifunctionalized compounds have been efficiently prepared by addition of carbonylated electrophiles to the 2-lithio derivative of 5-phenyloxazole preliminarily equipped with an oxazoline unit at the 4-position of the oxazole nucleus. It is demonstrated that this protocol offers a double advantage since it suppresses the troublesome electrocyclic ring-opening reaction and allows access to the target compounds by simple chemical transformation of the oxazoline ring system.