3376-32-7

Basic information

• Product Name: N-Benzylidene-O-methylhydroxylamine
• Synonyms: Benzaldehyde O-methyl oxime;N-Benzylidene-O-methylhydroxylamine;N-Methoxybenzenemethaneimine;O-Methylbenzaldoxime;O-Methyl-N-benzylidenehydroxylamine
• CAS NO: 3376-32-7
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.1632
• Mol File: 3376-32-7.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 223.9°Cat760mmHg
• Flash Point: 121.9°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.0537mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: N-Benzylidene-O-methylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzylidene-O-methylhydroxylamine(3376-32-7)
• EPA Substance Registry System: N-Benzylidene-O-methylhydroxylamine(3376-32-7)

Safety Data

• Hazardous Substances Data: 3376-32-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 1565, 1994 DOI: 10.1016/S0040-4039(00)76759-1

InChI:InChI=1/C8H9NO/c1-7-4-2-3-5-8(7)6-9-10/h2-6,10H,1H3/b9-6+

Upstream product

• 3272-27-3 N-methoxy-urea 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 67-62-9 O-Methylhydroxylamin 
• 20056-98-8 N-benzyl-N-methoxyamine 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 100-51-6 benzyl alcohol 
• 593-56-6 N-methoxylamine hydrochloride 
• 67-56-1 methanol 
• 101854-96-0 1-(4-bromo-phenyl)-3-methoxyamino-3-phenyl-propan-1-one 
• 1774-95-4 diethyl-N-methoxyphosphamide 
• 1569-76-2 N-methoxy-α-phenylnitrone 

Downstream Products

• 552-89-6 2-nitro-benzaldehyde 
• 1007358-38-4 (4R,5S)-1,5-dimethyl-3-((3S,4S)-3-methyl-4-phenyl-3,4-dihydro-azet-2-yl)-4-phenyl-imidazolidin-2-one 
• 62740-72-1 N-phenyl-(1-phenylpentyl)amine 
• 1865-12-9 N-(diphenylmethyl)aniline 
• 20056-98-8 N-benzyl-N-methoxyamine 
• 91-00-9 Benzhydrylamine 
• 119-61-9 benzophenone 
• 1013-88-3 Benzophenone imine 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-47-0 benzonitrile 
• 67-62-9 O-Methylhydroxylamin 
• 100-52-7 benzaldehyde 
• 99-61-6 3-nitro-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Compound and application thereof

The compound has the structure shown in the formula (I) or the formula (II) and R. 1 Selected from H. Deuterium, halogen, cyano, nitro, alkenyl, alkynyl, carboxy, C1 - C20 chain alkyl, C3 - C20 cycloalkyl, C1 - C20 alkoxy, substituted or unsubstituted C6 - C60 aryl, substituted or unsubstituted C3 - C60 heteroaryl, and the heteroatom in the heteroaryl is selected from O or S. L Is one selected from a single bond, a substituted or unsubstituted C6 - C60 arylene group, a substituted or unsubstituted C3 - C60 heteroarylene group. R Is one selected from H, deuterium, halogen, cyano, nitro, alkenyl, alkynyl, carboxy, C1 - C20 chain alkyl, C3 - C20 cycloalkyl, C1 - C20 alkoxy, substituted or unsubstituted C6 - C60 aryl, substituted or unsubstituted C3 - C60 heteroaryl. Ar Is a substituted or unsubstituted C6 - C60 aryl group, a substituted or unsubstituted C3 - C60 heteroaryl group. When the compound is applied OLED devices, the device efficiency can be effectively improved, the driving voltage is reduced, and the compound is a good-performance electronic transmission material.

Nitrate promoted mild and versatile Pd-catalysed C(sp2)-H oxidation with carboxylic acids

A nitrate-promoted Pd-catalysed mild cross-dehydrogenative C(sp2)-H bond oxidation of oximes or azobenzenes with diverse carboxylic acids has been developed. In contrast to the previous catalytic systems, this protocol features mild conditions (close to room temperature for most cases) and a broad substrate scope (up to 64 examples), thus constituting a versatile method to directly prepare diverse O-aryl esters. Moreover, the superiority of the nitrate additive in this mild transformation was further determined by experimental and computational evidence.

Synthesis of 2-fluorocholine aryl carbonyl compounds

The invention provides a method for synthesizing 2-fluoroarylcarbonyl compounds, which comprises the following steps: converting arylcarbonyl compounds into corresponding carbonyl oxime ether compounds, mildly implementing aryl hydrocarbon chain direct fluoridation of high-selectivity oximido substituent group ortho-position in the presence of a palladium catalyst, a fluoridation reagent and additives, and finally, rehydrolyzing oxime ethers under the action of acid to obtain the 2-fluoroarylcarbonyl compounds. The fluoridation method has the advantages of mild reaction conditions, high substrate adaptability, high fluoridation selectivity and the like, is simple to operate, and has higher application research value.