6037-73-6

Basic information

• Product Name: 1H-Indole, 2,3-dihydro-1-(phenylmethyl)-
• CAS NO: 6037-73-6
• Molecular Formula: C15H15N
• Molecular Weight: 209.291
• Mol File: 6037-73-6.mol
• Article Data: 54

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2,3-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2,3-dihydro-1-(phenylmethyl)-(6037-73-6)
• EPA Substance Registry System: 1H-Indole, 2,3-dihydro-1-(phenylmethyl)-(6037-73-6)

Safety Data

• Hazardous Substances Data: 6037-73-6(Hazardous Substances Data)

Usage

Organic compound

Indole core structure
The compound has an organic structure based on the indole core, which is a bicyclic compound with a six-membered aromatic ring and a five-membered nitrogen-containing ring.

Phenylmethyl side chain

A phenyl group (a benzene ring with a methyl side chain) is attached to the indole core, contributing to the compound's properties and reactivity.

Pharmaceutical applications

Antipsychotic and antihypertensive drugs
The compound is commonly used in the production of medications that treat mental disorders (antipsychotics) and high blood pressure (antihypertensives).

Intermediate in synthesis

Organic compounds
1H-Indole, 2,3-dihydro-1-(phenylmethyl)serves as a starting material or intermediate in the synthesis of other organic compounds, making it a versatile building block in organic chemistry.

Potential applications

Medicine and organic chemistry
Due to its unique structure and properties, the compound has potential applications in both the medical field and the broader area of organic chemistry, including the development of new drugs and chemical processes.

Upstream product

• 7135-32-2 1-benzylindolin-2-one 
• 496-15-1 1-indoline 
• 100-44-7 benzyl chloride 
• 2039-87-4 2-chlorostyrene 
• 100-46-9 benzylamine 
• 1217-89-6 1-benzylisatin 
• 1233656-18-2 C₁₆H₁₉O₄P 
• 930-21-2 2-azetidinone 
• 65185-57-1 N-(2-(2-Bromophenyl)ethyl)-N-(phenylmethyl)amine 
• 16851-56-2 indolin-2-yl carboxylic acid 
• 100-39-0 benzyl bromide 
• 75780-68-6 N-benzylidene-β-(2-bromophenyl)ethylamin 
• 4657-12-9 sodium hydroxy(phenyl)methanesulfonate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 108619-08-5 (5-nitroindoline-1-yl)(phenyl)methanone 
• 65797-53-7 1-benzyl-α,α-bis(trifluoromethyl)-2,3-dihydro-1H-indole-5-methanol 
• 885340-13-6 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile 
• 160970-54-7 silodosin 
• 1217-89-6 1-benzylisatin 
• 1206163-56-5 1-benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 1278579-53-5 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzyl-indoline 
• 63263-84-3 N-benzylindoline-5-carboxaldehyde 
• 63263-88-7 1-benzyl-1H-indole-5-carbaldehyde 
• 6146-52-7 5-nitroindole 
• 107518-68-3 N-(1-benzoyl-6-nitro-indolin-5-yl)-acetamide 
• 108013-44-1 1-benzoyl-2,3-dihydro-5-amino-1H-indole 
• 32692-19-6 5-nitro-2,3-dihydro-1H-indole 
• 102493-65-2 N-benzyl-5-(2-nitrobuten-1-yl)-2,3-dihydroindole 

Relevant articles and documents

Hydrosilane-Mediated Electrochemical Reduction of Amides

Electrochemical reduction of amides was achieved by using a hydrosilane without any toxic or expensive metals. The key reactive ketyl radical intermediate was generated by cathodic reduction. Continuous reaction with anodically generated silyl radicals or zinc bromide resulted in chemoselective deoxygenation to give the corresponding amines.

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

Manganese-Catalyzed Regioselective Dehydrogenative C-versus N-Alkylation Enabled by a Solvent Switch: Experiment and Computation

The first base metal-catalyzed regioselective dehydrogenative alkylation of indolines using readily available alcohols as the alkylating reagent is reported. A single air-and moisture-stable manganese catalyst provides access to either C3-or N-alkylated indoles depending on the solvent used. Mechanistic studies indicate that the reaction takes place through a combined acceptorless dehydrogenation and hydrogen autotransfer strategy.