33786-33-3Relevant academic research and scientific papers
A new class of functionalized calix[4]arenes as neutral receptors for colorimetric detection of fluoride ions
Chawla, Har Mohindra,Shrivastava, Rahul,Sahu, Satya Narayan
experimental part, p. 1999 - 2005 (2009/02/07)
A new class of functionalized calix[4]arenes have been synthesized and evaluated for colorimetric detection of fluoride ions. The molecular receptor 4b selectively recognizes fluoride ions via H-bonds and subsequent deprotonation to elicit a distinct colo
Anti-Plasmodium activity of tetrazolium salts
Cui, Xilin,Vlahakis, Jason Z.,Crandall, Ian E.,Szarek, Walter A.
, p. 1927 - 1947 (2008/09/21)
We have previously reported that sulfated cyclodextrins inhibit the invasion of Plasmodium merozoites by interacting with receptors present on the surface of erythrocytes. The observation that tetrazolium salts formed stable complexes with the inhibitory sulfated cyclodextrins suggested that tetrazolium salts might have anti-Plasmodium activity as well. Evaluation of commercially available tetrazolium salts indicated that some were active in the low nanomolar range and showed specificity in their inhibition of Plasmodium. Synthesis of a further 54 structures allowed us to determine that activity results from an aromatic component attached to the tetrazolium carbon atom (R1) and its size is not critical to the activity of the compound. Nitro modifications of active compounds are poorly tolerated, however, the presence of halogen atoms on aromatic groups attached to the nitrogen atoms of the tetrazolium ring (R2 and R3) has little effect on activity. Methoxy groups are tolerated on R2 and R3 components; however, they are disruptive on the R1 component. The overall results suggest that the R1 component is interacting with a specific hydrophobic environment and the R2 and R3 components are less constrained. The activity of these compounds in several human and mouse Plasmodium cultures suggests that the compounds interact with a component of the parasite that is both essential and conserved.
Fluoride-selective colorimetric sensors based on hydrazone functionality
Zhou, Lili,Zhang, Xiaohong,Wu, Shikang
, p. 850 - 851 (2007/10/03)
Hydrazone derivatives 2, 3, 5, 6 with H-bond donor and color-reporting chromophore were synthesized to be used as chemosensors for selective detecting anionic species via naked eye and absorption spectroscopy. The results revealed that these compounds exh
Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage
Hwu, Jih Ru,Lin, Chun Chieh,Chuang, Shih Hsien,King, Ke Yung,Su, Tzu-Rong,Tsay, Shwu-Chen
, p. 2509 - 2515 (2007/10/03)
Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N·) and iminyl (R2C=N·) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular φX174 RFI DNA at pH6.0 resulted in single-strand cleavage of DNA. Attachment of the electron-donating OMe group to arylhydrazones increased their DNA-cleaving activity. Results from systematic studies indicate that both the aminyl and the iminyl radicals possessed DNA-cleaving ability.
Synthesis, spectral and structural studies, and an evaluation of the hydrogen bonding of some phenylhydrazones
Kaberia, Festus,Vickery, Brian,Willey, Gerald R.,Drew, Michael G. B.
, p. 1622 - 1626 (2007/10/02)
A series of 46 phenylhydrazones, some novel, containing a variety of structural types has been synthesised. These have been studied by 1H n.m.r. and i.r. spectroscopy with respect to potential inter- and intra-molecular hydrogen bonding. ortho-Nitro or -carbonyl groups form strong hydrogen bonds to the imino-group which are readily observed by 1H n.m.r. but not by i.r. spectroscopy. 'Terminal' carbonyl groups also form strong hydrogen bonds to the imino-group and these can be detected by both i.r. and 1H n.m.r. spectroscopy. When both ortho-nitro- or -carbonyl groups and 'terminal' carbonyl groups are present the imino hydrogen atom is doubly hydrogen bonded and this is apparent in the 1H n.m.r. spectrum. The formation of an intramolecular hydrogen bond in the phenylhydrazone prevents the formation of an intermolecular hydrogen bond between the phenylhydrazone and a polar solvent.
