338404-77-6

Usage

Uses

Used in Pharmaceutical Industry:
2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol is used as a potential therapeutic agent for the treatment of various diseases. Its unique chemical structure, including the trifluoromethyl group, contributes to its enhanced stability and bioavailability, which are crucial for drug development.
Further research is necessary to fully understand and explore the potential applications of 2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol in pharmacology and medicine. Its current applications are primarily in the realm of research and development, with the aim of identifying its therapeutic potential and optimizing its use for specific medical conditions.

Upstream product

• 79424-03-6 ethyl 4,4,4-trifluoro-2-butynate 
• 51285-26-8 pyridine-2-carboxamidine hydrochloride 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 438249-84-4 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine 

Relevant academic research and scientific papers

Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

4-Amino-2-(pyridin-2-yl)pyrimidine as microbicidal active substances

There are described compounds of formula whereinR1 and R2 are each independently of the other hydrogen; unsubstituted or mono- or polyhalo-substituted C1-C20alkyl, C1-C20alkoxy, C2-C20alkenyl, C2-C20alkynyl, C3-C18cycloalkyl, C3-C7cycloalkyl-C1-C20alkyl; hydroxy; C1-C6alkoxy-C1-C20alkyl; carboxy; C1-C6alkyloxycarbonyl; cyano; mono- or di-C1-C20alkylamino; C1-C6alkylamino-C1-C20alkyl; halogen; phenyl; unsubstituted or C1-C5alkyl-, halo- or hydroxy-substituted phenyl-C1-C20alkyl, phenoxy or phenyl-C1-C20alkoxy; or R1 and R2 form a polymethylene chain of formula -(CH2)m- wherein m = 2-12;R3 is unsubstituted C7-C20alkyl; or amino-, hydroxy-, carboxy- or C1-C6alkyloxycarbonyl-substituted C2-C20alkyl; C8-C18cycloalkyl; C8-C20alkenyl; C8-C20alkynyl; C3-C7cycloalkyl-C8-C20alkyl; C1-C4alkoxy-C8-C20alkyl; R7R8N-C7-C20alkyl; phenyl; phenyl-C1-C4alkyl; or phenyl-C1-C4alkoxy;R4 is hydrogen; unsubstituted or C1-C5alkyl-, halo- or hydroxy-substituted C1-C20alkyl, C2-C20alkenyl, C2-C20alkynyl, C3-C20cycloalkyl, C3-C7cycloalkyl-C1-C20alkyl, C1-C20alkoxy-C1-C6alkyl or R7R8N-C1-C20alkyl, phenyl, phenyl-C1-C20alkyl or phenoxy-C1-C20alkyl;R5 and R6 are each independently of the other hydrogen; C1-C20alkyl; C2-C20alkenyl; C2-C20-alkynyl; C3-C18cycloalkyl; C3-C7cycloalkyl-C1-C20alkyl; hydroxy; C2-C20alkoxy; C1-C6alkoxy-C1-C20alkyl; carboxy; C1-C6alkyloxycarbonyl; cyano; nitro; C1-C20alkylamino; C1-C20alkylaminoalkyl; C1-C20haloalkyl; C1-C20haloalkoxy; halogen; unsubstituted or C1-C5alkyl-, halo- or hydroxy-substituted phenyl, phenoxy or phenyl-C1-C20alkyl or phenyl-C1-C20alkoxy; or R5 and R6 together form a polymethylene chain of formula -(CH2)m- wherein m = 2-12; andR7 and R8 are each independently of the other hydrogen; C1-C20alkyl; C3-C20alkenyl; C3-C20-alkynyl; C3-C7cycloalkyl; C3-C20cycloalkyl-C1-C4alkyl; phenyl; or phenyl-C1-C4alkyl. They are suitable for the antimicrobial treatment of surfaces, as antimicrobial active substances against gram-positive and gram-negative bacteria.