3385-61-3

Basic information

• Product Name: 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol
• Synonyms: 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol;3A,4,5,6,7,7A-Hexahydro-4,7-methanoinden-6-ol;4,7-Methano-1H-inden-6-ol, 3A,4,5,6,7,7A-hexahydro-;Einecs 222-197-4;Tricyclo(5.2.1.02,6)dec-3-en-8-ol;3A,4,5,6,7,7A-HEXAHYDRO-3H-4,7-METHANO-INDEN-5-OL
• CAS NO: 3385-61-3
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.21756
• EINECS: 222-197-4
• Mol File: 3385-61-3.mol

Chemical Properties

• Boiling Point: 245.9°Cat760mmHg
• Flash Point: 90.2°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 0.00462mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol(3385-61-3)
• EPA Substance Registry System: 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol(3385-61-3)

Safety Data

• Hazardous Substances Data: 3385-61-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides. Its role in these industries is crucial for creating effective and innovative products.
Used in Medicinal Applications:
Due to its antioxidant and anti-inflammatory properties, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol is of interest for potential medicinal applications. It may be employed as a therapeutic agent to combat oxidative stress and inflammation, which are implicated in numerous diseases and conditions.
Used in the Fragrance Industry:
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-6-ol is used as a key component in the fragrance industry to produce sweet, floral, and woody scents. Its incorporation in perfumes and personal care products enhances the sensory experience and adds depth to the olfactory profile of these products.

InChI:InChI=1/C10H14O/c11-10-5-6-4-9(10)8-3-1-2-7(6)8/h1-2,6-11H,3-5H2

Upstream product

• 77-73-6 bi(cyclopentadiene) 
• 64-18-6 formic acid 
• 933-60-8 exo-dicyclopentadiene 
• 1755-01-7 endo-Dicyclopentadien 

Downstream Products

• 10271-42-8 Octahydro-endo-4,7-methanoinden-endo-5-ol 
• 13380-94-4 octahydro-4,7-methano-inden-5-one 
• 14888-58-5 (1RS,2SR,6RS,7RS)tricyclo[5.2.1.02,6]dec-3-en-8-on 
• 13380-89-7 tricyclo[5.2.1.02,6 ]deca-8-yl alcohol 

Relevant articles and documents

Method of preparing tricyclic decenol, reaction intermediate and preparation method of reaction intermediate

The invention relates to a method of preparing tricyclic decenol, a reaction intermediate and a preparation method of the reaction intermediate. The preparation method of tricyclic decenol comprises the steps of allowing dicyclopentadiene and trifluoroacetic acid to give an addition reaction to form tricyclodecenyl trifluoroacetate, and performing hydrolysis through potassium carbonate to form tricyclic decenol. The preparation method is low in reaction temperature, short in time, and environmentally friendly; the quantity of reaction pollutants is small; a yield of a tricyclic decenol productcan reach 94%; and at the same time, the purity of tricyclic decenol can reach 98%.

The anisotropic effect of functional groups in 1H NMR spectra is the molecular response property of spatial nucleus independent chemical shifts (NICS) - Conformational equilibria of exo/endo tetrahydrodicyclopentadiene derivatives

The inversion of the flexible five-membered ring in tetrahydrodicyclopentadiene (TH-DCPD) derivatives remains fast on the NMR timescale even at 103 K. Since the intramolecular exchange process could not be sufficiently slowed for spectroscopic evaluation, the conformational equilibrium is thus inaccessible by dynamic NMR. Fortunately, the spatial magnetic properties of the aryl and carbonyl groups attached to the DCPD skeleton can be employed in order to evaluate the conformational state of the system. In this context, the anisotropic effects of the functional groups in the 1H NMR spectra prove to be the molecular response property of spatial nucleus independent chemical shifts (NICS).

Enantioselectivity in odor perception synthesis and olfactory properties of the new tricyclic sandalwood odorant Fleursandol

The 3-methyl-4-(tricyclo[5.2.1.02,6]dec-4-en-8-ylidene)butan-2- ols (=Fleursandol; rac-10), a new class of sandalwood odorants, were synthesized in their enantiomerically pure forms by use of tricyclo[5.2.1.0 2,6]dec-4-en-8-ones 17 and ent-17 and (tetrahydro-2H-pyran-2-yl)- protected 4-bromo-3-methylbutan-2-ols 22 and ent-22 as starting materials (Schemes 2-4). Only four of 16 possible stereoisomers of rac-10 possess the typical, very pleasant, long-lasting sandalwood odor (Table 1). The (2S,3R,4E,1′R,2′R,6′R,7′R)-isomer ent-10a is by far the most important representative, with an odor threshold of 5 μg/l in H 2O.

Synthesis and Reactions of Tricyclic Monocarboxylic Acid Esters

A convenient and efficient method for preparing tricyclic esters has been developed on the basis of addition of C1-C3 monocarboxylic acids to tricyclo2,6>deca-3,8-diene and its dimethyl derivatives in the presence of p-toluenesulfonic acid.The orientation of the ester group in the products has been determined.Some reactions of the resulting esters have been studied, and their possible applications have been proposed.

Vapor-phase Hydration of Dicyclopentadiene Catalyzed by Niobic Acid

Vapor-phase hydration of dicyclopentadiene in a flow system was promoted by niobic acid.Maximum conversion to the hydrated product was obtained at around the boiling point of dicyclopentadiene, 170 deg C.Niobic acid rapidly decreased its catalytic activity when it was heat-treated at temperatures higher than 300 deg C.