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Isavuconazole is a pharmaceutical drug belonging to the class of antifungal medications known as triazoles. It is characterized by its ability to inhibit the synthesis of ergosterol, an essential component of the fungal cell membrane, which leads to the disruption of the fungal cell structure and ultimately causes its death. The drug is available in both oral and intravenous formulations, and its broad spectrum of antifungal activity makes it a valuable option for the treatment of a variety of fungal infections. Isavuconazole has been shown to be effective and well tolerated, with a relatively low risk of adverse effects compared to other antifungal agents.

338990-63-9

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338990-63-9 Usage

Uses

Used in Pharmaceutical Industry:
Isavuconazole is used as an antifungal agent for the treatment of invasive aspergillosis and invasive mucormycosis, two serious fungal infections that typically affect individuals with compromised immune systems. Its broad-spectrum antifungal activity and relatively low risk of adverse effects make it a valuable option for treating a variety of fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 338990-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,8,9,9 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 338990-63:
(8*3)+(7*3)+(6*8)+(5*9)+(4*9)+(3*0)+(2*6)+(1*3)=189
189 % 10 = 9
So 338990-63-9 is a valid CAS Registry Number.

338990-63-9Downstream Products

338990-63-9Relevant academic research and scientific papers

N-substituted carbamoyloxyalkyl-azolium derivatives

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Page/Page column 43, (2010/02/09)

N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.

Ohwada, Jun,Tsukazaki, Masao,Hayase, Tadakatsu,Oikawa, Nobuhiro,Isshiki, Yoshiaki,Fukuda, Hiroshi,Mizuguchi, Eisaku,Sakaitani, Masahiro,Shiratori, Yasuhiko,Yamazaki, Toshikazu,Ichihara, Shigeyasu,Umeda, Isao,Shimma, Nobuo

, p. 191 - 196 (2007/10/03)

A highly potent water soluble triazole antifungal prodrug, RO0098557 (1), has been identified from its parent, the novel antifungal agent RO0094815 (2). The prodrug includes a triazolium salt linked to an aminocarboxyl moiety, which undergoes enzymatic activation followed by spontaneous chemical degradation to release 2. Prodrug 1 showed high chemical stability and water solubility and exhibited strong antifungal activity against systemic candidiasis and aspergillosis as well as pulmonary aspergillosis in rats.

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