32399-12-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(Methylamino)pyridine-3-methanol is used as an intermediate in the synthesis of various drugs for its ability to be incorporated into the molecular structures of pharmaceutical compounds, contributing to their therapeutic properties.
Used in Agrochemical Industry:
2-(Methylamino)pyridine-3-methanol is used as an intermediate in the synthesis of agrochemicals for its role in creating molecules with pesticidal or herbicidal activity, enhancing crop protection and yield.
It is important to handle 2-(Methylamino)pyridine-3-methanol with care and follow proper safety protocols when working with it due to its reactivity and potential hazards in chemical synthesis processes.

InChI:InChI=1/C7H10N2O/c1-8-7-6(5-10)3-2-4-9-7/h2-4,10H,5H2,1H3,(H,8,9)

Upstream product

• 32399-13-6 2-(methylamino)pyridine-3-carboxylic acid 
• 338990-71-9 methyl 2-formamidonicotinate 
• 232951-83-6 tert-butyl 2-chloropyridine-3-carboxylate 
• 2942-59-8 2-chloronicotinic acid 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 338990-70-8 tert-butyl 2-(methylamino)pyridine-3-carboxylate 

Downstream Products

• 128271-33-0 Methyl-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 127555-45-7 1-Methyl-3-phenylsulfanyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one 
• 338990-31-1 N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester 
• 1239164-10-3 1-(ethylthiomethyl)-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1,8-naphthyridin-2(1H)-one 
• 1239164-58-9 3-oxo-1-cyclohexenyl 1-(ethylthiomethyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 338990-63-9 1-[[N-methyl-N-3-[(t-butoxycarbonylmethylamino)acetoxymethyl]pyridin-2-yl]carbamoyloxy]ethyl-1-[(2R,3R)-2-(2,5-difluorophenyl)-2-hydroxy-3-[4-(4-cyanophenyl)thiazol-2-yl]butyl]-1H-[1,2,4]triazol-4-ium chloride 

Relevant academic research and scientific papers

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

A pharmaceutical intermediate 2 - methylamino -3 - pyridine methanol preparation method (by machine translation)

The invention relates to a shakang [...] sulfate intermediate preparation method, the intermediate [...][...] sulfate for 2 - methylamino - 3 - pyridine methanol, comprising: make stated 2 - methylamino - 3 - pyridine carboxylic acid tert-butyl in the organic solvent and sodium borohydride or potassium borohydride/Lewis acid/Lewis acid in the presence of a reducing agent for the reduction of 2 - methylamino - 3 - pyridine methanol. The method of the invention low cost, high product yield and purity, mild condition, easy controlled, suitable for industrial production. (by machine translation)

A preparation method of the midbody shakang zuo

The invention relates to a preparation method of an isavuconazole intermediate. The isavuconazole intermediate is 2-methylamino-3-pyridylcarbinol. The method comprises the following steps: (1) reacting 2-chloronicotinic acid with methylamine dissolved in a methylamine solution to generate 2-methylamino-3-pyridylformic acid, wherein the methylamine solution is formed by dissolving methylamine in water, methanol or a water-methanol mixture; and (2) reducing the 2-methylamino-3-pyridylformic acid in a solvent in the presence of a reducer sodium borohydride/iodine, sodium borohydride/Lewis acid or red aluminum to obtain the 2-methylamino-3-pyridylcarbinol. The method has the advantages of low cost, high product yield and purity, and mild and controllable conditions, and is suitable for industrial scale-up production.

RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES

Provided are 2-pyridone derivatives which have excellent herbicidal activity and exhibit high safety to useful crops and so on; salts thereof; and herbicides containing same. In more detail, 2-pyridone derivatives represented by general formula [I] or agrochemically acceptable salts thereof, and herbicides containing these compounds are provided. In general formula [I], X1 is an oxygen atom or a sulfur atom; X2, X3, and X4 are to each CH or N(O)m; m is an integer of 0 or 1; R1 is a hydrogen atom, a C1-12 alkyl group, or the like; R2 is a halogen atom, a cyano group, or the like; n is an integer of 0 to 4; R3 is a hydroxyl group, a halogen atom, or the like; A1 is C(R11R12); A2 is C(R13R14) or C═O; A3 is C(R15R16); and R11, R12, R13, R14, R15, and R16 are each independently a hydrogen atom or a C1-6 alkyl group.

N-substituted carbamoyloxyalkyl-azolium derivatives

N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.

A highly potent water soluble triazole antifungal prodrug, RO0098557 (1), has been identified from its parent, the novel antifungal agent RO0094815 (2). The prodrug includes a triazolium salt linked to an aminocarboxyl moiety, which undergoes enzymatic activation followed by spontaneous chemical degradation to release 2. Prodrug 1 showed high chemical stability and water solubility and exhibited strong antifungal activity against systemic candidiasis and aspergillosis as well as pulmonary aspergillosis in rats.

Substituted 1,3-Dihydro-2H-pyrrolopyridin-2-ones as Potential Antiinflammatory Agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolopyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR).Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin- and leukotriene-derived products or arachidonic acid metabolism although these compounds exhibit no significant inhibitory activity against the cyclooxygenase and 5-lipoxygenase enzymes in vitro.Structure-activity relationships in this series are discussed.