339058-27-4Relevant academic research and scientific papers
Aluminum Chloride Promoted Cross-Coupling of Trisubstituted Enol Phosphates with Organozinc Reagents En Route to the Stereoselective Synthesis of Tamoxifen and Its Analogues
Kotek, Vladislav,Polák, Peter,Dvo?áková, Hana,Tobrman, Tomá?
, p. 5037 - 5044 (2016)
A new method for the stereoselective cross-coupling reaction of arylzinc chlorides with trisubstituted enol phosphates is described. The developed method requires aluminum chloride as a promoter, and the reaction conditions tolerate various functional groups. The observed reactivity pattern of trisubstituted enol phosphates was used for the stereoselective preparation of tamoxifen and its analogues.
Cobalt-catalyzed benzylzincation of alkynes
Murakami, Kei,Yorimitsu, Hideki,Oshima, Koichiro
supporting information; experimental part, p. 7688 - 7691 (2010/09/10)
Chemical Equotion Present Carbometalation: Cobalt salts catalyze benzylzincation of alkynes to afford benzylated multisubstituted alkenes with high regio- and stereoselectivity. The scope of the reaction is wide enough to apply unfunctionalized alkynes as well as arylacetylenes. The reaction offers a new route to the regio- and stereoselective synthesis of an estrogen receptor antagonist (see scheme).
