14994-03-7

Upstream product

• 100-44-7 benzyl chloride 
• 2785-29-7 benzyl potassium 
• 7446-70-0 aluminum (III) chloride 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 35192-30-4 2,6-Divinyltoluol 
• 35192-31-5 1,3-Di-<2'-methyl-phenyl>-buten-(1) 
• 1591-30-6 (1,1'-biphenyl)-4,4'-dicarbonitrile 
• 23450-31-9 4-benzylbenzonitrile 
• 611-45-0 1-Benzyl-naphthalene 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 613-42-3 4-benzylbiphenyl 
• 70827-66-6 tribenzylaluminium*diethyl etherate 
• 451-40-1 phenyl benzyl ketone 
• 5773-56-8 1,2-Diphenylethanol 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 339058-27-4 (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene 
• 108-88-3 toluene 

Relevant academic research and scientific papers

Rational Preparation of Well-Defined Multinuclear Iridium-Aluminum Polyhydride Clusters and Comparative Reactivity

We report an original alkane elimination approach, entailing the protonolysis of triisobutylaluminum by the acidic hydrides from Cp*IrH4. This strategy allows access to a series of well-defined tri- and tetranuclear iridium aluminum polyhydride clusters, depending on the stoichiometry: [Cp*IrH3Al(iBu)2]2(1), [Cp*IrH2Al(iBu)]2(2), [(Cp*IrH3)2Al(iBu)] (3), and [(Cp*IrH3)3Al] (4). Contrary to most transition-metal aluminohydride complexes, which can be considered as [AlHx+3]x-aluminates and LnM+moieties, the situation here is reversed: These complexes have original structures that are best described as [Cp*IrHx]n-iridate units surrounding cationic Al(III) fragments. This is corroborated by reactivity studies, which show that the hydrides are always retained at the iridium sites and that the [Cp*IrH3]-moieties are labile and can be transmetalated to yield potassium ([KIrCp*H3], 8) or silver (([AgIrCp*H3]n, 10) derivatives of potential synthetic interest. DFT calculations show that the bonding situation can vary in these systems, from 3-center 2-electron hydride-bridged Lewis adducts of the form Ir-H←Al to direct polarized metal-metal interaction from donation of d-electrons of Ir to the Al metal, and both types of interactions take place to some extent in each of these clusters.

Aluminum Chloride Promoted Cross-Coupling of Trisubstituted Enol Phosphates with Organozinc Reagents En Route to the Stereoselective Synthesis of Tamoxifen and Its Analogues

A new method for the stereoselective cross-coupling reaction of arylzinc chlorides with trisubstituted enol phosphates is described. The developed method requires aluminum chloride as a promoter, and the reaction conditions tolerate various functional groups. The observed reactivity pattern of trisubstituted enol phosphates was used for the stereoselective preparation of tamoxifen and its analogues.

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.