33920-28-4Relevant academic research and scientific papers
Quinoxalines X [1]. A new and convenient synthesis of 1H-pyrazolo[3,4-b]quinoxalines (flavazoles)
Sarodnick,Linker
, p. 829 - 836 (2007/10/03)
Quinoxaline-2-aldoximes and -ketoximes (6) react with hydrazine, alkylhydrazines or arylhydrazines under acidic conditions to afford 1H-pyrazolo[3,4-b]quinoxalines (flavazoles) (1). Since the oximes (6) are easily available from phenylenediamine, the herein described methodology provides a convenient two step entry to various functionalized flavazoles. Furthermore, acylation and alkylation of the 1-unsubstituted 1H-pyrazolo[3,4-b]quinoxalines 7 proceeds smoothly and in good yield to afford 31 different flavazoles 11 and 12.
Synthesis of 1-Phenyl-1H-pyrazolo-quinoxaline (1-Phenylflavazole) Derivatives Substituted at 3-Position
Pillai, P. Madhavan,Ramabhadran, P.
, p. 960 - 963 (2007/10/02)
3-Amino-, 3-chloro- and 3-hydroxy-1-phenyl-1H-pyrazoloquinoxalines (6,9 and 12) have been prepared starting from ethyl 2-hydroxyquinoxaline-3-carboxylate (1).The 3-amino derivative (12) is also obtained from a Hofmann reaction of 1-phenyl-1H-pyrazo
Phenylation and Dephenylation Reactions: Formation of 1H-Pyrazoloquinoxalines
Pillai, P. Madhavan,Ramabhadran, P.
, p. 901 - 904 (2007/10/02)
1,3-Diphenyl-1H-pyrazoloquinoxaline (9) has been isolated as a byproduct in the conversion of quinoxaline-2-carboxaldehyde phenylhydrazone (1) into 1-phenyl-1H-pyrazoloquinoxaline (5) using stored phenylhydrazine as the dehydrogenating agent
