33920-28-4

Upstream product

• 109179-52-4 3-chloro-1-phenyl-1H-pyrazolo<3,4-b>quinoxaline 
• 106696-52-0 Quinoxaline-2-carboxaldehyde p-bromophenylhydrazone 
• 17460-16-1 1-phenyl-3-(D-erythro-trihydroxypropyl)-1H-pyrazolo[3,4-b]quinoxaline 
• 40910-67-6 1-phenyl-1H-pyrazolo<3,4-b>quinoxaline-3-carboxaldehyde 
• 98591-61-8 2-hydroxyquinoxaline-3-carbonyl chloride 
• 36818-07-2 ethyl-3-hydroxy-quinoxaline-2-carboxylate 
• 1593-08-4 Quinoxaline-2-carboxaldehyde 
• 112032-32-3 2-formylquinoxaline oxime 
• 100-63-0 phenylhydrazine 
• 109002-26-8 quinoxaline-2-carboxaldehyde p-chlorophenylhydrazone 
• 109002-25-7 quinoxaline-2-carboxaldehyde p-tolylhydrazone 
• 62976-85-6 quinoxaline-2-carboxaldehyde phenylhydrazone 
• 109002-31-5 1-phenyl-1H-pyrazolo<2,3-b>quinoxaline-3-carboxylic acid 
• 100881-37-6 4-(2-amino-phenylimino)-2-phenyl-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 14428-35-4 1,3-diphenyl-1H-pyrazolo<3,4-b>quinoxaline 
• 109002-30-4 1-phenyl-3-trichloromethyl-1H-pyrazolo<3,4-b>quinoxaline 
• 106696-56-4 2-Anilinoquinoxaline-3-carboxylic acid 
• 106696-55-3 2-Anilinoquinoxaline-3-carboxamide 
• 106696-57-5 1-Phenylpyrazolo<3,4-b>pyrazine-5,6-dicarboxylic acid 
• 106696-53-1 1-(p-bromophenyl)flavazole 
• 106660-45-1 1-(p-chlorophenyl)-1H-pyrazolo<3,4-b>quinoxaline 
• 128499-80-9 1-p-chlorophenyl-3-chloro-1H-pyrazolo<3,4-b>quinoxaline 
• 109002-32-6 1-phenyl-3-(p-tolyl)-1H-pyrazolo<3,4-b>quinoxaline 
• 109002-31-5 1-phenyl-1H-pyrazolo<2,3-b>quinoxaline-3-carboxylic acid 

Relevant academic research and scientific papers

Quinoxalines X [1]. A new and convenient synthesis of 1H-pyrazolo[3,4-b]quinoxalines (flavazoles)

Quinoxaline-2-aldoximes and -ketoximes (6) react with hydrazine, alkylhydrazines or arylhydrazines under acidic conditions to afford 1H-pyrazolo[3,4-b]quinoxalines (flavazoles) (1). Since the oximes (6) are easily available from phenylenediamine, the herein described methodology provides a convenient two step entry to various functionalized flavazoles. Furthermore, acylation and alkylation of the 1-unsubstituted 1H-pyrazolo[3,4-b]quinoxalines 7 proceeds smoothly and in good yield to afford 31 different flavazoles 11 and 12.

Synthesis of 1-Phenyl-1H-pyrazolo-quinoxaline (1-Phenylflavazole) Derivatives Substituted at 3-Position

3-Amino-, 3-chloro- and 3-hydroxy-1-phenyl-1H-pyrazoloquinoxalines (6,9 and 12) have been prepared starting from ethyl 2-hydroxyquinoxaline-3-carboxylate (1).The 3-amino derivative (12) is also obtained from a Hofmann reaction of 1-phenyl-1H-pyrazo

Phenylation and Dephenylation Reactions: Formation of 1H-Pyrazoloquinoxalines

1,3-Diphenyl-1H-pyrazoloquinoxaline (9) has been isolated as a byproduct in the conversion of quinoxaline-2-carboxaldehyde phenylhydrazone (1) into 1-phenyl-1H-pyrazoloquinoxaline (5) using stored phenylhydrazine as the dehydrogenating agent