339333-00-5

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 100-39-0 benzyl bromide 
• 71879-55-5 ethyl 3-(piperid-4-yl)propionate 
• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 100-46-9 benzylamine 
• 133407-67-7 ethyl (E)-6-(benzyloxy)hex-2-enoate 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 124438-29-5 3-(1-Benzyl-piperidin-4-yl)-propan-1-ol 
• 124438-69-3 3-(1-Benzyl-piperidin-4-yl)-propionic acid,ethyl ester 

Downstream Products

• 1454273-52-9 ethyl 5-(1-benzylpiperidin-4-yl)-2-diazo-3-oxopentanoate 
• 1454273-53-0 ethyl 8-benzyl-2-oxo-8-azaspiro[4.5]decane-1-carboxylate 
• 1454273-54-1 ethyl 8-benzyl-2-ureido-8-azaspiro[4.5]dec-1-ene-1-carboxylate 
• 1454273-55-2 1'-benzyl-6,7-dihydrospiro[cyclopenta[d]pyrimidine-5.4'-piperidine]-2,4-(1H,3H)-dione 
• 1454273-51-8 ethyl 5-(1-benzylpiperidin-4-yl)-3-oxopentanoate 
• 364385-41-1 methyl (E)-3-{2-[(1-benzyl-4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate 
• 364385-42-2 methyl 3-{2-[2-(4-piperidinyl)ethyl]oxazolo[4,5-b]pyridin-6-yl}-2-propenoate 
• 124438-69-3 3-(1-Benzyl-piperidin-4-yl)-propionic acid,ethyl ester 
• 364385-39-7 2-[(1-benzyl-4-piperidinyl)ethyl]-6-bromooxazolo[4,5-b]pyridine 

Relevant academic research and scientific papers

GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides gonadotropin releasing hormone receptor antagonists and the pharmaceutical composition comprising the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease

Synthetic study of 4-substituted piperidine ring in elarofiban, RWJ-50042, tirofiban and paroxetine

A new strategy for synthesizing a 4-substituted piperidine ring uses the formal [3+3] cycloaddition reaction as the key protocol. This method provides a convenient formal synthesis of elarofiban, RWJ-50042, tirofiban and paroxetine.

Synthesis of substituted oxazolo[4,5-b]-pyridine derivatives

Synthesis of new functionnalized oxazolo[4,5-b]pyridines was described. 5-Bromo-3-hydroxy-2-aminopyridine was heated, in the presence of PPSE or PPA, with 4-cyanobenzoic acid, (4-piperidinyl)acetic or propanoic acid to afford 1,3-oxazolo derivatives. Intr