339587-72-3

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 56694-49-6 3-methyl-1-phenyl-1,5-dihydro-4H-pyrazol-4-one 
• 109-77-3 malononitrile 
• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 89-25-8 edaravone 

Relevant academic research and scientific papers

CsF promoted rapid synthesis of spirooxindole-pyran annulated heterocycles at room temperature in ethanol

A newer, versatile, and straightforward synthetic strategy for the construction of functionalized spirooxindole-pyran annulated heterocycles is described. The procedure is based on CsF-promoted rapid tandem Knoevenagel-Michael-Cyclocondensation reaction o

Novel organometallic nanomagnetic catalyst for multicomponent synthesis of spiroindoline derivatives

A novel, green, reusable polyaniline (PANI)/Fe3O4/carbon nanotube (CNT) nanomagnetic catalyst has been prepared, characterized by Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and X-ray diff

Synthesis and characterization of acetic acid functionalized poly (4-vinylpyridinium) salt as new catalyst for the synthesis of spiropyran derivatives and their biological activity

Acetic acid functionalized poly(4-vinylpyridinium) bromide (APVPB), as a new and heterogeneous catalyst, was designed and successfully tested on the synthesis of 2-aminospiro[indoline-3,4?pyran]-2-one and spiro[indeno[1,2-b]quinoxaline-11,4-pyran]-2?-amine derivatives. Also, infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), differential thermal gravimetric (DTG), scanning electron microscope (SEM), X-ray diffraction analysis (XRD) and energy dispersive X-ray analysis (EDX) of the catalyst has been studied in the presented work. The prepared spiro-pyrans were solved in DMSO and subjected to antioxidant activity screening by DPPH free radical scavenging assay and antifungal activity against Fusarium oxysporum. Results showed that the synthesized spiro-pyran possess strong antioxidant activity (IC50; 0.161 ± 0.009 to 1.509 ± 0.007 mg/ml) and also good inhibition activity against Fusarium oxysporum (65.8 ± 1.4% to 88.3 ± 2.2% at 500 ppm concentration and 89.2 ± 3.2% to 100 ± 0.0% at 1000 ppm concentration). For their biological activities, the prepared spiro-pyran compounds may be suggested to apply as alternative systems in medicine and agriculture.

Bovine serum albumin catalyzed one-pot, three-component synthesis of dihydropyrano[2,3-c]pyrazole derivatives in aqueous ethanol

Bovine serum albumin (BSA) catalyzed synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one pot, three component reaction of an aldehyde/ketone/isatin, malononitrile and 3-methyl-1H-pyrazol-5-(4H)-one in H2O-EtOH (7: 3) at ambient temp

Ultrasound promoted green synthesis of spiro[pyrano[2,3-c]pyrazoles] as antioxidant agents

Ultrasound promoted, cerium ammonium nitrate catalyzed sustainable synthesis of spiro[indoline3,4′-pyrano[2,3-c]pyrazole] derivatives (4a-l) is reported herein. The synthesized compounds were screened for their antioxidant activities as free radical scave

An investigatory study of antibacterial activity of functionalized spirooxindoles

Synthesis of functionalized spirooxindoles have been reviewed and it has been proposed that the unique core ring system that is common to this family of compounds arises by a biological Knoevengal-Michael-Domino cyclization along with the attachment of hy

Silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (SB-DBU)Cl as a highly efficient, heterogeneous and recyclable silica-supported ionic liquid catalyst for the synthesis of benzo[b]pyran, bis(benzo[b]pyran) and spiro-pyran derivatives

The reaction of 3-chloropropyl silica (SilprCl) with 1,8-diazabicyclo[5.4. 0]undec-7-ene (DBU) in dry acetone affords silica-bonded 5-n-propyl-octahydro- pyrimido[1,2-a]azepinium chloride (SB-DBU)Cl as a new silica-supported ionic liquid catalyst. Afterwa

Carbon-SO3H: A novel and recyclable solid acid catalyst for the synthesis of spiro[4H-pyran-3,3′-oxindoles]

A bioglycerol derived carbon-sulfonic acid is found to catalyze efficiently the three-component one-pot condensation of isatin, malononitrile, and 1,3-dicarbonyls to afford a wide range of spiro[4H-pyran-3,3′-oxindole] derivatives in good yields and selec

Efficient entry to diversely functionalized spirooxindoles from isatin and their biological activity

A collection of structurally complex and chemically diverse small molecules is a useful tool to explore cell circuitry. In this article, we have reported the two step synthesis of diverse spirooxindoles. The key reaction to assemble the spirooxindole core