33963-27-8

Basic information

• Product Name: Benzene, 1-ethoxy-2-methoxy-4-methyl-
• Synonyms: Homobrenzcatechin-3-methylaether-4-aethylaether;4-Aethoxy-3-methoxy-toluol;3-Methoxy-4-aethoxy-1-methyl-benzol;Benzene,1-ethoxy-2-methoxy-4-methyl;QOFRRWWZQIIACS-UHFFFAOYSA;4-ethoxy-3-methoxytoluene;Kreosolaethylaether
• CAS NO: 33963-27-8
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol File: 33963-27-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-ethoxy-2-methoxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-ethoxy-2-methoxy-4-methyl-(33963-27-8)
• EPA Substance Registry System: Benzene, 1-ethoxy-2-methoxy-4-methyl-(33963-27-8)

Safety Data

• Hazardous Substances Data: 33963-27-8(Hazardous Substances Data)

Upstream product

• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 94-71-3 2-Ethoxyphenol 
• 64-17-5 ethanol 
• 120-80-9 benzene-1,2-diol 
• 90-05-1 2-methoxy-phenol 
• 64-67-5 diethyl sulfate 
• 93-51-6 2-Methoxy-4-methylphenol 
• 75-03-6 ethyl iodide 

Downstream Products

• 102168-84-3 5,4'-diethoxy-4,3'-dimethoxy-2-methyl-benzophenone 
• 111497-39-3 bis-(5-ethoxy-4-methoxy-2-methyl-phenyl)-methane 
• 103095-41-6 4-ethoxy-5-methoxy-2-nitro-toluene 
• 111088-83-6 5,5'-diethoxy-4,4'-dimethoxy-2,2'-dimethyl-benzophenone 
• 103796-34-5 2-nitro-4,5-diethoxybenzoic acid 
• 103095-48-3 4-ethoxy-5-methoxy-2-nitro-benzoic acid 
• 671789-92-7 4,5-diethoxy-2-nitro-toluene 
• 99866-19-0 4-ethoxy-5-methoxy-phthalic acid 
• 861365-66-4 (5-ethoxy-4-methoxy-2-methyl-phenyl)-glyoxylic acid 
• 861299-18-5 5-ethoxy-4-methoxy-2-methyl-benzoic acid 
• 104736-43-8 N-(p-methoxyphenyl)-5-ethoxy-4-methoxy-2-methylbenzenepropanamide 
• 104736-42-7 N-(2-phenylethyl)-5-ethoxy-4-methoxy-2-methylbenzenepropanamide 
• 104736-41-6 N-benzyl-5-ethoxy-4-methoxy-2-methylbenzenepropanamide 
• 104736-39-2 N-(n-hexyl)-5-ethoxy-4-methoxy-2-methylbenzenepropanamide 

Relevant articles and documents

Highly selective conversion of guaiacol to: Tert -butylphenols in supercritical ethanol over a H2WO4 catalyst

The conversion of guaiacol is examined at 300 °C in supercritical ethanol over a H2WO4 catalyst. Guaiacol is consumed completely, meanwhile, 16.7% aromatic ethers and 80.0% alkylphenols are obtained. Interestingly, tert-butylphenols are produced mainly with a high selectivity of 71.8%, and the overall selectivity of 2,6-di-tert-butylphenol and 2,6-di-tert-butyl-4-ethylphenol is as high as 63.7%. The experimental results indicate that catechol and 2-ethoxyphenol are the intermediates. Meanwhile, the WO3 sites play an important role in the conversion of guaiacol and the Br?nsted acid sites on H2WO4 enhance the conversion and favour a high selectivity of the tert-butylphenols. The recycling tests show that the carbon deposition on the catalyst surface, the dehydration and partial reduction of the catalyst itself are responsible for the decay of the H2WO4 catalyst. Finally, the possible reaction pathways proposed involve the transetherification process and the alkylation process during guaiacol conversion.

CARBON-13 NUCLEAR MAGNETIC RESONANCE SPECTRAL STUDY. EFFECT OF O-METHYLATION OF ortho-SUBSTITUTED PHENOLS ON THE ARYL CARBON SHIELDING AND ITS APPLICATION TO INTERPRETATION OF THE SPECTRA OF SOME FLAVONOIDS

The O-methylation effect on the carbon-13 nuclear magnetic resonance ((13)C-NMR) chemical shifts of aryl carbons of the ortho-monosubstituded phenols has been investigated.In phenols with nonconjugated substituents (2-11), O-methylation caused an upfield shift by an averange of 4.1 ppm for the ortho-methine carbon (C-6), whereas it caused a downfield shift by an averange of 1.1 ppm for the substituted ortho-carbon (C-2).This regularity is very useful for the spectral interpretation of some natural products with an ortho-substituted phenol group, such as flavonoids (16-20 and 22).The O-methylation effect of phenols 12-15 with conjugated ortho-substituents on the aryl carbons, especially C-1, C-2 and C-5, differed significantly from that observed in 2-11.On the basis of a limited number of examples, the O-ethylation effect on aromatic carbons seems similar to the O-methylation effect.Keywords---(13)C-NMR; O-methylation shift; phenol (NMR); ortho-substituted phenol (NMR); flavonoid; puerarin; 4',7-di-O-methylpuerarin; O-ethylation shift