3400-80-4Relevant academic research and scientific papers
Physically mixed catalytic system of amino and sulfo-functional porous organic polymers as efficiently synergistic co-catalysts for one-pot cascade reactions
Bian, Guomin,Huang, Xianpei,Liu, Fuyao,Qi, Yonglin,Sun, Zunming,Yang, Xinlin,Yang, Xinyue,Zhang, Mengmeng,Zhang, Wangqing
, p. 9546 - 9556 (2020/06/17)
In this article, acid/base bi-functional polymeric materials were prepared using physically mixed porous poly(divinylbenzene-co-4-vinylbenzenesulfonic acid) (P(DVB-VBS)) with sulfonic acid groups and poly(divinylbenzene-co-4-vinylbenzyl amine) (P(DVB-VBA)) with amino groups, which were synthesized by solvothermal polymerization of crosslinker DVB with either phenyl 4-vinylbenzenesulfonate (PVBS) or 4-vinylbenzyl amine hydrochloride (VBAH) functional monomers together with subsequent hydrolyzation or alkaline treatment. The bi-functional polymeric materials were utilized as a synergistic catalytic system for one-pot cascade reactions including deacetalization-Henry condensation reaction, deacetalization-Knoevenagel condensation reaction and the transformation of 3,4-dihydropyran derivatives to α-ester cyclohexenone compounds. The crosslinked polymeric frameworks effectively isolated sulfonic acid and primary amine groups to ensure their roles as both acid and base catalyst simultaneously in a one-pot system. The hierarchical porosity of a physically mixed acid/base co-catalyst system provided the possibility for the multi-step transformation of more complex substrates.
Hollow Hyper-Cross-Linked Nanospheres with Acid and Base Sites as Efficient and Water-Stable Catalysts for One-Pot Tandem Reactions
Jia, Zhifang,Wang, Kewei,Tan, Bien,Gu, Yanlong
, p. 3693 - 3702 (2017/06/09)
A task-specific functionalized hyper-cross-linked polymer (HCP) with hollow spherical structure was synthesized by an easily accessible Friedel-Crafts reaction-based approach. A harmonious coexistence of acid (sulfonic acid) and base (amine) sites on a microporous organic material was achieved. The acid-base bifunctional HCP catalyst (HCP-A-B) structure was fully characterized by many physicochemical methods. In the subsequent tandem reactions (hydrolysis/Henry and hydrolysis/Knoevenagel reactions), the HCP-A-B catalyst displayed high catalytic efficiency and chemical stability toward water or organic solvent. These HCP-A-B catalyst characteristics led to the development of a previously unreported transformation of 2-ethoxy-3,4-dihydropyran derivative to a 2-cyclohexen-1-one derivative through a tandem reaction involving water-assisted ring-opening hydrolysis of the dihydropyran, an intramolecular aldol reaction, and a dehydration reaction. In all of these reactions, the bifunctional HCP-A-B catalyst can be recovered and reused more than 10 times without significant loss of activity.
Arginase Inhibitors and Their Therapeutic Applications
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Paragraph 0564; 0565; 0566, (2017/11/29)
Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a
Design, synthesis, structure, and dehydrogenation reactivity of a water soluble o-iodoxybenzoic acid derivative bearing a trimethylammonium group
Cui, Li-Qian,Dong, Zhi-Lei,Liu, Kai,Zhang, Chi
supporting information; experimental part, p. 6488 - 6491 (2012/02/02)
5-Trimethylammonio-1, 3-dioxo-1, 3-dihydro-1λ5-benzo[d][1, 2]iodoxol-1-ol anion (AIBX 1a), an o-iodoxybenzoic acid (IBX) derivative having the trimethylammonium moiety on its phenyl ring, possesses very good solubility in water and distinct oxidative properties from IBX, which is demonstrated in the oxidation of various β-keto esters to the corresponding dehydrogenated products using water as cosolvent. The regeneration of AIBX 1a can be easily realized from the reaction mixture due to its good water solubility.2011 American Chemical Society.
A radical cyclization approach to the formal total syntheses of platencin
Palanichamy, Kalanidhi,Subrahmanyam, Ayyagari V.,Kaliappan, Krishna P.
experimental part, p. 7877 - 7886 (2011/12/13)
Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-g
A tandem amination/lactamisation route to 2-Azabicyclo[2.2.2]octanones
Cuthbertson, James D.,Godfrey, Andrew A.,Taylor, Richard J. K.
scheme or table, p. 2805 - 2807 (2010/12/25)
An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.
(3-Carbethoxy-2-oxopropylidene)triphenylphosphorane. A Reagent for "3+3" Cyclohexenone Annulation
Pietrusiewicz, K. Michal,Monkiewicz, Jaroslaw
, p. 788 - 790 (2007/10/02)
The development of a new cyclohexenone annulation reaction of general scope which utilizes α,β-unsaturated aldehydes and (3-carbethoxy-2-oxopropylidene)triphenylphosphorane is reported.
