340161-69-5

Basic information

• Product Name: tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate
• Synonyms: tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate
• CAS NO: 340161-69-5
• Molecular Weight: 278.395
• Mol File: 340161-69-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate(340161-69-5)
• EPA Substance Registry System: tert-butyl (S)-(1-(dimethylamino)-3-phenylpropan-2-yl)carbamate(340161-69-5)

Safety Data

• Hazardous Substances Data: 340161-69-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 29802-26-4 N-[(2S)-2-amino-3-phenylpropyl]-N,N-dimethylamine 
• 123665-42-9 (S)-2-Amino-N,N-dimethyl-3-phenyl-propionamide hydrochloride 
• 78800-68-7 (S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 124-40-3 dimethyl amine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 141403-49-8 (2S)-2-[N-(tert-butoxycarbonyl)amino]-3-phenyl-O-(4-methylphenylsulfonyl)propan-1-ol 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 29802-26-4 N-[(2S)-2-amino-3-phenylpropyl]-N,N-dimethylamine 

Relevant articles and documents

PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS

The invention includes procedures for stereoselective β-arylation of carboxylic acids having a β-carbon atom. For example, stereoselective arylation procedures include the following reactions: (I)

Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains

In the present study we have synthesized a new class of 4-aminoquinoline derivatives via replacement of the diethylamine functionality of chloroquine (CQ) with acyclic and/or cyclic amine groups containing basic tertiary terminal nitrogen and bioevaluated them for antimalarial activity against Plasmodium falciparum in vitro (CQ-sensitive strain-3D7 & CQ-resistant strain-K1) and Plasmodium yoelii in vivo (N-67 strain). Among the series, thirteen compounds showed superior antimalarial activity against K1 strain as compared to CQ. In addition, all these analogs showed 100% suppression of parasitaemia on day 4 in the in vivo mouse model against N-67 strain when administered orally. Further, biophysical studies suggest that these compounds act on the heme polymerization target.

New chiral auxiliaries for the construction of quaternary stereocenters by copper-catalyzed Michael reactions

The construction of quaternary stereocenters with 95-99% ee at ambient temperatures can be achieved by a copper-catalyzed Michael reaction with the application of α-amino acid amides as chiral auxiliaries [Eq. (1)]. These amides can be obtained in a few steps from the α-amino acids with standard transformations and, after the Michael reaction, they can be quantitatively recovered. Exclusion of water and oxygen is not necessary.