34041-00-4Relevant academic research and scientific papers
One-pot formation of aza-enolates from secondary amines and condensation to esters and alkyl bromides
Chevalley, Alice,Férézou, Jean-Pierre
experimental part, p. 5882 - 5889 (2012/09/11)
Starting from commercial secondary amines, a one-pot procedure allows a direct access to enaminones through a one-pot deprotonation/oxidation/in situ re-deprotonation/acylation sequence without intermediate isolation of the intermediate Schiff base or its corresponding enamine tautomer. An alternative one-pot sequence involving a similar oxidation step followed by one or two alkylation steps yields, after acidic work-up, functionalized ketones directly from the parent amine. This process has been applied to an expeditious synthesis of the male aggregation pheromone of the cereal leaf beetle Oulema melanopus.
KHSO4 assisted Michael addition-elimination reactions of formylated acetophenones in water: A facile general green synthetic route to 3-(alkyl/aralkyl/aryl)amino-1-arylprop-2-en-1-ones
Devi,Dutta,Nongkhlaw,Vishwakarma
, p. 739 - 742 (2011/08/09)
A facile general green synthetic route to 3-(alkyl/aralkyl/aryl)amino-1- arylprop-2-en-1-ones in excellent yields has been developed by reacting formylated acetophenones with primary amines assisted by KHSO4 in water.
