34064-31-8

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 100-63-0 phenylhydrazine 
• 383-63-1 ethyl trifluoroacetate, 
• 59-88-1 phenylhydrazine hydrochloride 
• 407-25-0 trifluoroacetic anhydride 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 

Downstream Products

• 125972-09-0 N-α-Chlorotrifluoroacetylimino-N'-phenylhydrazidodichlorophosphate 
• 125972-15-8 2,2,2-Trifluoro-3-phenyl-5-trifluoromethyl-1,3,4,2λ⁵-oxadiazaphospholine 
• 125972-13-6 O,O-Diethyl-N-phenyl-N'-trifluoroacetylhydrazidophosphate 
• 125972-14-7 O,O-Diisopropyl-N-phenyl-N'-trifluoroacetylhydrazidophosphate 
• 125972-11-4 2,2,2-Triethoxy-3-phenyl-5-trifluoromethyl-1,3,4,2λ⁵-oxadiazaphospholine 
• 125972-12-5 2,2,2-Triisopropoxy-3-phenyl-5-trifluoromethyl-1,3,4,2λ⁵-oxadiazaphospholine 
• 126366-48-1 Bis-(3-phenyl-5-trifluoromethyl-1,3,4,2λ⁵-oxadiazaphospholine)-2-(N-trifluoroacetyl-N'-phenylhydrazido)spirophosphorane 
• 1374227-53-8 2,2,2-trifluoro-N'-(4-methoxyphenyl)-N'-phenylacetohydrazide 
• 91152-81-7 1-trimethylsiloxy-2,2,2-trifluoroacetone phenylhydrazone 
• 1515830-54-2 1-phenyl-3,7-bis(trifluoromethyl)-1,4-dihydro-1,2,4-benzotriazin-4-yl 
• 1515830-53-1 1-phenyl-3-trifluoromethyl-1,4-dihydro-benzo[e][1,2,4]triazin-4-yl 
• 1515830-08-6 2,2,2-Trifluoro-N′-[2-nitro-5-(trifluoromethyl)phenyl]-N′-phenylacetohydrazide 
• 1515830-05-3 2,2,2-Trifluoro-N′-(2-nitrophenyl)-N′-phenylacetohydrazide 
• 1073951-15-1 methyl (4-oxo-3-phenyl-1,2,3,4-tetrahydrophthalazin-1-yl)acetate 

Relevant academic research and scientific papers

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3-CF3-Pyrazoles from Nitrilimines and Isoxazolidinediones

1,4-Diaryl-5-carboxamido substituted 3-trifluoromethylpyrazoles are obtained with exclusive regioselectivity under transition-metal-free conditions. This decarboxylative [3+2] cycloaddition protocol was enabled by employing trifluoromethyl nitrilimines as 1,3-dipoles, and isoxazolidinediones as CO2-masked alkynyl dipolarophiles. The applicability of this method is further manifested by its compatibility with difluoromethyl, alkyl, aryl, and heteroaryl nitrilimines, as well as the preparation of 4-carboxylic amido analogue of drug Celebrex. (Figure presented.).

Heterocyclic derivatives of fullerene C60. 1. Synthesis of new fulleropyrazolines by the 1,3-dipolar cycloaddition of nitrile imines

New stable [6,6]-closed cycloadducts, fulleropyrazolines containing aryl, hetaryl, trifluoromethyl, and other substituents in the five-membered ring, have been obtained by the 1,3-dipolar cycloaddition of nitrile imines to C 60. Two methods of generating nitrile imines in situ have been used, the dehydrohalogenation of the corresponding hydrazonoyl halides by the action of triethylamine and the thermal decomposition of 2,5-diaryltetrazoles.

SYNTHESIS OF 2,2,2-TRISUBSTITUTED 5-TRIFLUOROMETHYL-Δ4-1,3,4,2-OXADIAZAPHOSPHOLINES AND THEIR POTENTIALITY AS PRECURSORS OF TRIFLUOROACETONITRILE IMINES

N'-Phenyl- and methyltrifluoroacetohydrazides react with phosphorus pentachloride to give the corresponding 2,2,2-trichloro-3-phenyl- and methyl-Δ4-1,3,4,2-oxadiazaphospholines, from which various 2,2,2-trisubstituted derivatives are further synthesized.Heating 3-phenyl-2,2,2-tris(p-tolyloxy) analog with an excess of styrene affords 1,5-diphenyl-3-trifluoromethyl-2-pyrazoline, which indicates that the phospholine behaves as a precursor of trifluoroacetonitrile phenylimine.