34069-57-3 Usage
Uses
Used in Medicinal Chemistry:
DL-4-Amino-2-fluorobutyric acid is used as a building block in the synthesis of other biologically active compounds. Its unique properties, due to the presence of a fluorine atom, make it a valuable component in the development of new pharmaceuticals.
Used in Drug Development:
DL-4-Amino-2-fluorobutyric acid is used as a precursor in the development of drugs targeting the GABA system. The GABA system plays a crucial role in various neurological functions, and compounds that modulate this system can have potential therapeutic applications in treating conditions such as anxiety, epilepsy, and other neurological disorders.
Used in Research Applications:
Due to its unique properties and potential for interaction with the GABA system, DL-4-Amino-2-fluorobutyric acid is used in research to study the mechanisms of action and potential therapeutic effects of GABAergic drugs. This can help in the discovery of novel drug candidates and the understanding of the underlying biology of neurological disorders.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DL-4-Amino-2-fluorobutyric acid is used as a key intermediate in the synthesis of various GABAergic drugs. Its unique structural features and potential for enhancing drug efficacy make it an important compound in the development of new therapeutic agents for neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 34069-57-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,0,6 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 34069-57:
(7*3)+(6*4)+(5*0)+(4*6)+(3*9)+(2*5)+(1*7)=113
113 % 10 = 3
So 34069-57-3 is a valid CAS Registry Number.
34069-57-3Relevant academic research and scientific papers
Chemistry of 4-fluoroglutamic acid. Part 3. Preparation of the diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine. An enzymatic access to the antipodes of 4-amino-2-fluorobutyric acid
Tolman, Vladimír,Sedmera, Petr
, p. 5 - 10 (2007/10/03)
The pure diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine were prepared from the corresponding 4-fluoroglutamic acids. Glutamic decarboxylase treatment of the acids led to chiral 2-fluoroGABA.
Resolution of γ-Methyl and γ-Fluoroglutamic Acids. Lack of Stereospecificity of Leucine Aminopeptidase with L-Leucyl-L-erythro-γ-substituted Glutamates
Bory, Sonia,Dubois, Joelle,Gaudry, Michel,Marquet, Andree,Lacombe, Liliane,Weinstein, Shulamith
, p. 475 - 480 (2007/10/02)
The hydrolysis of L-leucyl-γ-substituted D,L-glutamates by leucine aminopeptidase, from porcine kidney, is stereospecific with threo-γ-methyl and threo-γ-fluoroglutamate containing dipeptides whereas there is a lack of stereospecificity with erythro-isomers.The optical purities of L-threo- and L-erythro-glutamate isomers thus obtained have been monitored by gas chromatography, high pressure liquid chromatography, or nuclear magnetic resonance.The optical rotations of optically pure L-isomers have been measured and the discrepancies with former publications are discussed.
