149117-03-3

Basic information

• Product Name: D-Glutamic acid, 4-fluoro-, (4R)- (9CI)
• Synonyms: D-Glutamic acid, 4-fluoro-, (4R)- (9CI)
• CAS NO: 149117-03-3
• Molecular Formula: C5H8FNO4
• Molecular Weight: 165.1197232
• Product Categories: GLYCINESCAFFOLD
• Mol File: 149117-03-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-Glutamic acid, 4-fluoro-, (4R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: D-Glutamic acid, 4-fluoro-, (4R)- (9CI)(149117-03-3)
• EPA Substance Registry System: D-Glutamic acid, 4-fluoro-, (4R)- (9CI)(149117-03-3)

Safety Data

• Hazardous Substances Data: 149117-03-3(Hazardous Substances Data)

Upstream product

• 618-27-9 hydroxy L-proline 
• 51-35-4 4R-4-hydroxyproline 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 13504-86-4 (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline 
• 7682-53-3 2-Acetamino-2,4-dicarboxy-4-fluor-glutarsaeuretetramethylester 
• 23115-42-6 ethyl 2-acetamidoacrylate 
• 685-88-1 fluoromalonic acid diethyl ester 
• 2708-77-2 D,L-erythro,threo-4-fluoroglutamic acid 
• 148267-92-9 (2S,4S)-2-Amino-4-fluoro-pentanedioic acid dimethyl ester; hydrochloride 
• 149117-03-3 (+/-)-threo-4-Fluoroglutamic acid 
• 67943-19-5 methyl (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylate 
• 132651-95-7 N-acetyl-4(R)-fluoro-L-proline methyl ester 
• 78804-96-3 (2S,4S)-1-acetyl-4-hydroxyproline methyl ester 

Downstream Products

• 95048-75-2 methyl trans-3-fluoro-2-pyrrolidone-5-carboxylate 
• 149117-03-3 d-threo-(2R,4R)-4-Fluoroglutamic acid 
• 95048-75-2 methyl cis-3-fluoro-2-pyrrolidone-5-carboxylate 
• 5130-17-6 (+/-)-2-Fluoro-4-aminobutanoic acid 
• 132746-47-5 (-)-D-erythro-4-fluoroglutamic acid 
• 7682-57-7 3-Fluor-pyrrolidon-2-carbonsaeure-5 
• 34069-57-3 (R)-4-Amino-2-fluorobutyric acid 
• 34069-57-3 (S)-4-Amino-2-fluorobutyric acid 
• 149117-03-3 (+/-)-threo-4-Fluoroglutamic acid 
• 32563-25-0 (2S,4S)-L-threo-4-fluoroglutamic acid 
• 32563-24-9 (2S,4R)-L-erythro-4-fluoroglutamic acid 

Relevant articles and documents

PREPARATIVE SEPARATION OF 4-FLUOROGLUTAMIC ACID STEREOISOMERS

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Chemistry of 4-fluoroglutamic acid. Part 2. Separation of the diastereomers on a large scale. Preparation of cis- and trans-4-fluoro-5-pyrrolidone-2-carboxylic acids (4-fluoropyroglutamic acids)

Separation of the 4-fluoroglutamic acid diastereomers has been achieved by crystalization of the hydrochlorides of their dialkyl esters 1b and 2d.Subsesquent hydrolysis afforded the diastereomers 1a and 2a in 100percent steric purity.Conversion of the acids into the 5-methyl esters followed by treatment with ammonia gives rise to the trans and cis isomers of 4-fluoro-5-pyrrolidine-2-carboxylic acid, 3 and 4.NMR data are given.

[F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, derivatives thereof and use thereof and processes for their preparation

The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION

The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

Chemistry of 4-fluoroglutamic acid. Part 3. Preparation of the diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine. An enzymatic access to the antipodes of 4-amino-2-fluorobutyric acid

The pure diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine were prepared from the corresponding 4-fluoroglutamic acids. Glutamic decarboxylase treatment of the acids led to chiral 2-fluoroGABA.