340809-43-0

Upstream product

• 110-85-0 piperazine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 192773-96-9 [4-(4-benzyloxyphenyl)-butyl]-[2-[2-(3,5-dimethylphenyl)-5-hydroxy-1H-indol-3-yl]ethyl]carbamic acid benzyl ester 
• 7021-11-6 4-(4-hydroxyphenyl)butanoic acid 
• 20776-45-8 5-benzyloxytryptamine 
• 6686-26-6 4-(4-benzyloxyphenyl)butyric acid 
• 100-39-0 benzyl bromide 
• 53157-45-2 N-[2-(5-benzyloxy-indol-3-yl)-ethyl]-phthalimide 
• 192182-48-2 2-[2-(5-benzyloxy-2-bromo-1H-indol-3-yl)ethyl]isoindole-1,3-dione 
• 192182-34-6 2-[2-[5-benzyloxy-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl]isoindole-1,3-dione 
• 192773-93-6 3-(2-aminoethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-ol 
• 192773-94-7 4-(4-benzyloxyphenyl)-N-{2-[2-(3,5-dimethylphenyl)-5-hydroxy-1H-indol-3-yl]ethyl]butyramide 
• 192773-95-8 3-[2-[4-(4-benzyloxyphenyl)butylamino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-ol 
• 192771-98-5 4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol 

Relevant academic research and scientific papers

SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.