543745-10-4

Upstream product

• 340962-84-7 1-(1-benzylpiperidin-4-yl)-piperidin-2-one 
• 543745-08-0 1-(4-methoxyphenyl)-7-oxo-6-(4-piperidinyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 543745-05-7 1-(1-benzyl-4-piperidinyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone 
• 543745-04-6 1'-benzyl-3,3-dichloro-1,4'-bipiperidin-2-one 
• 543745-09-1 6-[1-(2-formylphenyl)-4-piperidinyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 74-89-5 methylamine 
• 4509-90-4 5-bromovaleroyl chloride 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 543745-06-8 ethyl 6-(1-benzyl-4-piperidinyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 
• 543745-07-9 ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 

Relevant academic research and scientific papers

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues

The synthesis, SAR, pharmacokinetic profile, and modeling studies of both monocyclic and fused pyrazoles containing substituted N-arylpiperidinyl P4 moieties that are potent and selective factor Xa inhibitors will be discussed. Fused pyrazole analog 16a,

Substituted amino methyl factor Xa inhibitors

The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.