34213-86-0Relevant articles and documents
Glycodendrimer synthesis without using protecting groups
Kieburg, Christoffer,Lindhorst, Thisbe K.
, p. 3885 - 3888 (1997)
Oligoantennary neoglycoconjugates can act as powerful inhibitors of carbohydrate-protein interactions and thus serve as antiadhesives in carbohydrate-based adhesion systems. They were obtained by a procedure that doesn't require protecting groups. Various unprotected NCS-functionalized saccharides were coupled with oligoamines in aqueous solution. This versatile method is generally applicable to the synthesis of thiourea-bridged glycodendrimers.
Glycosyl-based united cell penetrating peptide-modified brain-targeted nano-liposome as well as preparation method and application thereof (by machine translation)
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, (2020/06/30)
The invention relates to a glycosyl combined cell penetrating peptide-modified brain-targeted nano-liposome and a preparation method and application thereof, and belongs to the technical field of targeted drug delivery. The liposome comprises EPC, CHO, glycosyl modified polyethylene glycol phospholipid and cell penetrating peptide modified polyethylene glycol phospholipid with a certain molar ratio. By simultaneously modifying the glycosyl and the cell penetrating peptide on the surface of the nano liposome, the nano lipidosome has the capability of actively targeting brain and penetrating cell membranes. The drug carrier is used for a drug carrier, so that the carried medicines can efficiently and specifically target brain tissues and enter into brain cells to play a role. The in-vitro cell test and the in-vivo distribution experiment prove that the brain-targeted nano-liposome provided by the invention can reach the brain smoothly and accumulate in brain cells to exert efficacy. (by machine translation)
Diazirine-functionalized mannosides for photoaffinity labeling: Trouble with FimH
Beiroth, Femke,Koudelka, Tomas,Overath, Thorsten,Knight, Stefan D.,Tholey, Andreas,Lindhorst, Thisbe K.
, p. 1890 - 1900 (2018/08/21)
Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial fo
COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
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Page/Page column 69-70, (2011/05/06)
The present invention encompasses compounds and methods for treating urinary tract infections.