785-79-5

Usage

Uses

Used in Fragrance and Flavor Industry:
4-Phenyl ethyl benzoic acid is used as a key ingredient in the production of fragrances and flavors due to its aromatic properties, enhancing the sensory experience of various consumer products.
Used in Pharmaceutical Industry:
4-Phenyl ethyl benzoic acid serves as a precursor in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Dye Industry:
This chemical compound is utilized in the production of dyes, providing coloration and enhancing the visual appeal of various products.
Used in Research and Development:
4-Phenyl ethyl benzoic acid is studied for its potential anti-inflammatory and anti-cancer properties, making it a subject of interest in the development of new therapeutic agents and treatments for various medical conditions.

Upstream product

• 13041-75-3 (E)-4-stilbenecarboxylic acid 
• 13024-49-2 4-aminodibenzyl 
• 79-37-8 oxalyl dichloride 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 75-36-5 acetyl chloride 
• 1149-18-4 (E)-methyl 4-styrylbenzoate 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 536-74-3 phenylacetylene 
• 42497-80-3 methyl 4-(phenylethynyl)benzoate 
• 586-76-5 4-Bromobenzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 3277-89-2 phenethylmagnesium bromide 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 124-38-9 carbon dioxide 

Downstream Products

• 100-21-0 terephthalic acid 
• 65-85-0 benzoic acid 
• 173781-70-9 4-Phenethyl-benzoyl chloride 
• 1356067-58-7 (+/-)-tetrahydro-2H-pyran-2-ylmethyl 4-(2-phenylethyl)benzoate 
• 1356067-54-3 (+/-)-oxiran-2-ylmethyl 4-(2-phenylethyl)benzoate 
• 34224-29-8 (4-phenethylphenyl)methanol 
• 323205-99-8 methyl 3-(4-(cyclohexylmethoxy)phenyl)-2(S)-((2-(2-phenylethyl)phenyl)carbonylamino)propionate 
• 118298-62-7 4'-<2-(4-benzoylphenyl)ethyl>-2,4,6-triisopropylbenzophenone 
• 118298-65-0 (4-{2-[4-(7-Hydroxy-3,5-diisopropyl-8,8-dimethyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-phenyl]-ethyl}-phenyl)-phenyl-methanone 

Relevant academic research and scientific papers

Development of Dipeptidic hGPR54 Agonists

A series of dipeptides were designed as potential agonists of the human KiSS1-derived peptide receptor (hGPR54). While the sequence Arg-Trp-NH2was the most efficient in terms of affinity, we established a convergent synthetic strategy to optimi

Modulators of methyl modifying enzymes, compositions and uses thereof

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein

Direct carboxylation of arenes and halobenzenes with CO2 by the combined use of AlBr3 and R3SiCl

The Lewis acid-mediated direct carboxylation of aromatic compounds with CO2 is efficiently promoted by the addition of silyl chlorides bearing three alkyl and/or aryl substituents in total on the silicon atom. Thus, toluene, xylenes, mesitylene, and some other alkylbenzenes are treated with a 1:1 mixture of AlBr3 and Ph3SiCl in neat substrates under CO2 pressure (3.0 MPa) at room temperature, to give the corresponding carboxylic acids in 60-97% yields, based on AlBr3. Polycyclic arenes, including naphthalene, phenanthrene, and biphenyl, are regioselectively carboxylated in 91-98% yields with the aid of 1 molar equiv of AlBr3 and Ph3SiCl in an appropriate solvent, chosen from benzene, chlorobenzene, and fluorobenzene. These solvents, as well as bromobenzene, resist carboxylation; however, they are also carboxylated in moderate yields when treated with a 1:5 mixture of AlBr3 and iPrSiCl at elevated temperatures. The FT-IR spectrum of a mixture prepared by exposing a suspension of AlBr3 and Ph3SiCl in cyclohexane to CO 2 exhibits an absorption band around 1650 cm-1, assigned to the C=O stretching vibration of a species consisting of CO2, AlBr3, and Ph3SiCl, which suggests that the silyl chlorides activate CO2 in cooperation with AlBr3. 1H NMR analysis of unworked-up reaction mixtures reveals that the products merge as aluminum carboxylates. The mass balance concerning silicon indicates that the silyl chlorides are recycled during the reaction sequence. On the basis of these observations, a feasible mechanism is proposed for the present carboxylation.

Alpha-helical mimetics

Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

Amine Compounds

There is provided a compound exhibiting an activity of suppressing immune response with reduced adverse drug reactions, which compound is useful in the chemotherapy for preventing or treating, for example, a wide range of various autoimmune diseases including systemic erythematodes, chronic rheumatoid arthritis, Type I diabetes, inflammatory bowel disease, biliary cirrhosis, uveitis, multiple sclerosis or other disorders, or chronic inflammatory diseases, or cancers, lymphoma or leukemia, or resistance to organ or tissue transplantation or rejection against transplantation. Novel amine compounds having an S1P1/Edg1 receptor agonist effect, possible stereoisomers or racemic bodies of the compounds, or pharmacologically acceptable salts, hydrates or solvates of the compound, the stereoisomers or the racemic bodies, or prodrugs of the compounds, the stereoisomers, the racemic bodies, the salts, the hydrates or the solvates, are provided.

4-Aminoquinolines: Novel nociceptin antagonists with analgesic activity

Small-molecule nociceptin antagonists were synthesized to examine their therapeutic potential. After a 4-aminoquinoline derivative was found to bind with the human ORL1 receptor, a series of 4-aminoquinolines and related compounds were synthesized and their binding was evaluated. Elucidation of structure - Activity relationships eventually led to the optimum compounds. One of these compounds, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide hydrochloride (11) not only antagonized nociceptin-induced allodynia in mice but also showed analgesic effect in a hot plate test using mice and in a formalin test using rats. Its analgesic effect was not antagonized by the opioid antagonist naloxone. These results indicate that this nociceptin antagonist has the potential to become a novel type of analgesic that differs from μ-opioid agonists.

Reduction of olefins on solid support using diimide

The reduction of solid supported olefinic substrate using diimide is described. The diimide, prepared from sulfonylhydrazide, was found to efficiently reduce the olefinic substrates. Typically, the reaction proceeds in over 90% yield to afford the reduction product cleanly after cleavage from the Wang resin.

Liquid Crystalline Asymmetric Bisphenyl-4,4'-bibenzyldicarboxylates and Polysiloxanes with Bisphenyl-4,4'-bibenzyldicarboxylat Components in the Side Chains, Synthesis and Characterization

Asymmetric bisphenyl bibenzyl-4,4'-dicarboxylates with an alkenyloxy- or the 10-undecenoylgroup in the p-position of one terminal benzene ring and the butyl-, an alkoxy- or the thiomethylgroup in the p-position of the other terminal benzene ring (12-14) are synthesized.The olefins 12-14 are added to a poly(methylhydrogensiloxane) 15 to give mesomorphic side chain polysiloxanes 16-18.Data of liquid crystalline properties of 12-14, 16-18 and precursors are discussed.