3423-30-1

Usage

General Description

8-ethyl-8-azabicyclo[3.2.1]octan-3-one is a chemical compound with a bicyclic structure containing a nitrogen atom. It is commonly known as tropanone and is a derivative of tropane. Tropanone is used as an intermediate in the synthesis of various pharmaceutical drugs, particularly those targeting the central nervous system. It is a chiral compound, meaning it has two mirror-image isomers, and its stereochemistry plays a crucial role in its pharmacological activity. Tropanone derivatives have been studied for their potential therapeutic effects, including as analgesics, anti-dementia agents, and treatments for substance abuse. Additionally, tropanone derivatives have been investigated for their potential use in the treatment of depression and anxiety disorders.

Upstream product

• 64429-16-9 4-ethylamino-n-butylamine 
• 638-37-9 butanedial 
• 557-66-4 ethanamine hydrochloride 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 542-05-2 acetonedicarboxylic acid 
• 75-04-7 ethylamine 
• 6132-04-3 trisodium citrate dihydrate 

Relevant academic research and scientific papers

Metabolism of N-alkyldiamines and N-alkylnortropinones by transformed root cultures of Nicotiana and Brugmansia

A range of analogues of N-methylputrescine and tropinone were fed to transformed root cultures of Nicotiana rustica and/or a Brugmansia candida x aurea hybrid. These cultures were made by the transformation of the relevant plant species with Agrobacterium rhizogenes. A number of the metabolites, notably those showing a relatively modest alteration in the N-alkyl substituent, were metabolized in vivo to form homologues of the normal alkaloids biosynthesized by these roots. These products were identified by GC/MS and comparison with some synthetic reference materials. Analogues with major alterations in the size of the N-alkyl substituent were not metabolized at all. In the N. rustica cultures, the analogues fed at 1 mM significantly affected the profile of normal alkaloids, with up to a 4-fold diminution in nicotine being found in the presence of N-n-propylputrescine. The ratio between alkaloids of the pyrrolidine series and the piperideine series was also affected. In contrast, the presence of the analogues in the B. candida x aurea hybrid culture at 1 mM did not inhibit or substantially interfere with the accumulation of the normal spectrum of alkaloids. The potential for using these cultures to make complex novel products from simple precursors is discussed.

Salts of endo-8-methyl-8-syn-alkyl-8-azoniabicyclo-[3.2.1]-octane-3-alkylcarboxylates, and therapeutic compositions containing them

The invention relates to new salts of endo-8-methyl-8-syn-alkyl-8-azoniabicyclo-[3.2.1]-octane-3-alkylcarboxylates, of formula: STR1 in which R1 is a linear or branched alkyl radical of 2-5 C atoms, a cycloalkyl radical of 3-6 C atoms, or a phenyl-alkyl radical, R3 and R4, which can be the same or different, are alkyl radicals of 1-6 C atoms, X is a halide ion. The new compounds are potent spasmolytics.