71336-83-9

Upstream product

• 67-56-1 methanol 
• 69489-40-3 D-2-[p-(benzyloxy)phenyl]glycine 
• 342898-56-0 (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid methyl ester 
• 100-39-0 benzyl bromide 
• 22818-40-2 D-4-hydroxyphenylglycine 

Downstream Products

• 63856-16-6 trimethyl <αR,α'R,α''R>-α,α',α''-tri(4-benzyloxyphenyl)hexahydro-1,3,5-triazine-1,3,5-triacetate 
• 87568-48-7 methyl D-α-methylacrylamido-α-((p-benzyloxy)phenyl)acetate 
• 180715-66-6 (R)-4-Benzyloxyphenyl-N-methylglycinamide 
• 201608-19-7 (2R,5R)-1-Benzoyl-5-(4-benzyloxyphenyl)-2-tert-butyl-3-methylimidazolidin-4-one 
• 201608-24-4 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzoic acid ethyl ester 
• 201608-20-0 (2R,5S)-1-Benzoyl-5-(4-benzyloxyphenyl)-2-(tert-butyl)-3,5-dimethylimidazolidin-4-one 
• 201608-21-1 Trifluoro-methanesulfonic acid 4-((2R,4S)-3-benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl ester 
• 169209-65-8 MPPG 
• 201608-23-3 4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-benzonitrile 
• 201608-22-2 [4-((2R,4S)-3-Benzoyl-2-tert-butyl-1,4-dimethyl-5-oxo-imidazolidin-4-yl)-phenyl]-phosphonic acid diethyl ester 
• 1159576-40-5 C₂₉H₃₈N₂O₇ 
• 78246-50-1 methyl (L)-N^α-phthaloylseryl-(D)-p-benzyloxyphenylglycinate 
• 83160-23-0 N-phthaloyldehydroalanyl(p-benzyloxyphenyl)glycine methyl ester 
• 64232-07-1 (4-Benzyloxy-phenyl)-[(S)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-oxo-azetidin-1-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies

Novel α-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.

Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds

The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotina

Stereoselective synthesis of (S)-MPPG, (S)-MTPG and (S)-(+)-αM4CPG from (R)-4-hydroxyphenylglycine

(R)-4-Hydroxyphenylgrycine was protected with a benzyl group and a methyl group was introduced at the α position by using the self-regeneration-of-stereocentre method. After the 4-hydroxy group had been converted into the corresponding trifluoromethanesulfonate (triflate), three palladium-catalyzed reactions were employed to furnish (S)-α-methyl-4-phosphonophenylglycine [(S)-MPPG], (S)-α-methyl-4-(tetrazol-5-yl)phenylglycine [(S)-MTPG] and (S)-4-carboxyphenyl-α-methylglycine [(S)-αM4CPG], a class of new and selective antagonists of metabotropic glutamate receptors.

Stereoselective synthesis of (S)-(+)-αM4CPG, a selective antagonist of metabotropic glutamate receptors

The synthesis, from (R)-4-hydroxyphenylglycine, of (+)-α-methyl-4- carboxy-phenylglycine ((+)-αM4CPG), a new and selective antagonist of metabotropic glutamate receptor, and assignment of its absolute configuration, are described.