34320-89-3

Upstream product

• 38109-73-8 ethyl 4-trimethylsiloxy-4-phenylpropenoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 516-12-1 N-iodo-succinimide 

Downstream Products

• 119448-82-7 ethyl 2-phenylimidazo[1,2-a] pyridine-3-carboxylate 
• 64399-23-1 ethyl 4-phenyl-2-aminothiazole-5-carboxylate 
• 6297-65-0 ethyl 3-oxo-3-phenyl-2-(phenylsulfonyl)propanoate 
• 60903-90-4 diethyl 2,3-dibenzoylmaleate 
• 93729-29-4 ethyl 2,5-diphenyloxazole-4-carboxylate 

Relevant academic research and scientific papers

NIS-TBHP promoted oxidative coupling of C–N and C–O bonds: A metal-free approach to polysubstituted oxazoles

A metal-free approach to polysubstituted oxazoles via the oxidative coupling of readily available benzylamines and 1,3-dicarbonyl derivatives in the presence of an external base has been developed. A variety of functional groups on both of the starting materials are tolerated using this method, affording the corresponding oxazoles in moderate to good yields. Iodination was proposed as the initiation step of the reaction and a plausible mechanism has been proposed to explain the reaction pathway.

Preparation method for 2-halogenated-1,3-dicarbonyl derivative

The invention discloses a preparation method for a 2-halogenated-1,3-dicarbonyl derivative. The preparation method is suitable for wide 1,3-dicarbonyl derivatives. The raw materials are easy to obtain, and multiple varieties are achieved. The product obtained through the method is diversified in type, and can be directly used and used for other further reactions. According to the method, reaction conditions are gentle, the reaction operation and after-treatment process is simple, reaction time is short, the yield is high, pollution is low, and the preparation method is suitable for industrial production.

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy

An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, α,β-unsaturated ketones, β-keto esters and 2-aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis.

I2/Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: Application to synthesis of pyrazine, β-carboline and quinoxalines

A self-sorting domino reaction of aryl β-ketoesters into symmetrical 1,4-enediones is reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, 1,4-enediones were successfully employed for the synthesis of bioactive pyrazine, β-carboline and quinoxalines via aza-Michael addition, intramolecular cyclization and C-C bond cleavage of 1,3-dicarbonyl unit under mild reaction condition. This journal is

Iodine-catalysed sp3 C-H sulfonylation to form β-dicarbonyl sulfones with sodium sulfinates

An efficient and easily handled method for β-dicarbonyl sulfones with sodium sulfinates as the sulfonyl source was developed. This transformation was involved in the iodine-catalysed sp3 C-H sulfonylation of β-dicarbonyl compounds. This journal

A useful and convenient synthetic protocol for iodination of organic substrates using a combination of vanadyl acetylacetonate, hydrogen peroxide, and sodium iodide

A wide variety of organic substrates can be iodinated selectively in good yields by employing a combination of vanadyl acetylacetonate, hydrogen peroxide, and sodium iodide at ice-bath temperature. Good yield, selectivity, use of cost effective reagents, and mild and environmentally benign reaction conditions are some of the major advantages of this protocol.

I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea

A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis.

TBAI-catalyzed oxidative coupling of aminopyridines with β-keto esters and 1,3-diones - Synthesis of imidazo[1,2-a]pyridines

TBAI could catalyze the direct oxidative C-N coupling of 2-aminopyridines with β-keto esters and 1,3-diones, which affords imidazo[1,2-a]pyridines as the products. The reaction was realized under metal-free conditions by using tert-butyl hydroperoxide (TB

Formation of unsymmetrical 1,4-enediones via A focusing domino strategy: Cross-coupling of 1,3-dicarbonyl compounds and methyl ketones or terminal aryl alkenes

A highly efficient synthesis of unsymmetrical 1,4-enediones from 1,3-dicarbonyl compounds and methyl ketones or terminal aryl alkenes has been developed via a focusing domino strategy. Simple and readily available starting materials, mild reaction conditions, and a very simple operation are advantages of the reaction, which allow straightforward synthesis of a variety of unsymmetrical 1,4-enediones.

Aerobic oxidative iodination of ketones catalysed by sodium nitrite "on water" or in a micelle-based aqueous system

Selective and efficient aerobic oxidative iodination of ketones in aqueous media was achieved by using molecular iodine as the source of iodine atoms, air as the terminal oxidant, sodium nitrite (NaNO2) as the catalyst and H2SO4