38109-73-8

Basic information

• Product Name: 2-Propenoic acid, 3-phenyl-3-[(trimethylsilyl)oxy]-, ethyl ester
• CAS NO: 38109-73-8
• Molecular Formula: C14H20O3Si
• Molecular Weight: 264.397
• Mol File: 38109-73-8.mol

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-3-[(trimethylsilyl)oxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-3-[(trimethylsilyl)oxy]-, ethyl ester(38109-73-8)
• EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-3-[(trimethylsilyl)oxy]-, ethyl ester(38109-73-8)

Safety Data

• Hazardous Substances Data: 38109-73-8(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 38109-69-2 N,O-bis(trimethylsilane)acetamide 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 637041-06-6 2-Phenyl-2-trimethylsilanyloxy-cyclopropanecarboxylic acid ethyl ester 
• 1197995-87-1 (+)-(2S,3R,5S)-benzyl-2-(1-(ethoxycarbonyl)-2-oxo-2-phenylethyl)-5-methyl-3-(pivaloyloxy)piperidine-1-carboxylate 
• 1197995-88-2 (-)-(2S,3R,5R)-benzyl-2-(1-(ethoxycarbonyl)-2-oxo-2-phenylethyl)-5-methyl-3-(pivaloyloxy)piperidine-1-carboxylate 
• 10539-50-1 diethyl 2-benzoylsuccinate 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 34320-89-3 2-iodo-3-oxo-3-phenyl-propionic acid ethyl ester 
• 92975-30-9 diethyl 3-phenyl-3-trimethylsiloxy-1,2-cyclopropanedicarboxylate 

Relevant articles and documents

Synthesis of All diastereomers of the piperidine - alkaloid substructure of cyclopamine

"Chemical Equation Presented" All four diastereomers of the trisubstituted piperidine-alkaloids of the veratramine and jervine type were synthesized with complete stereocontrol starting from enantiopure citronellic acids. The flexible, high-yielding, and scalable route described here will facilitate convergent syntheses and give access to analogues of cyclopamine and other biologically active and diverse steroid alkaloids.

CONVERSION OF 1,3-DICARBONYLS TO 1,4-DICARBONYLS

The cyclopropanation of β-trimethylsiloxy α,β-unsaturated esters and ketones, prepared from 1,3-dicarbonyl compounds, with carbenes followed by ring cleavage gave corresponding 1,4-dicarbonyl compounds in moderate yields.