343617-78-7

Basic information

• Product Name: N-(4-(trifluoromethyl)phenyl)benzothioamide
• Synonyms: N-(4-(trifluoromethyl)phenyl)benzothioamide
• CAS NO: 343617-78-7
• Molecular Weight: 281.301
• Mol File: 343617-78-7.mol

Chemical Properties

• CAS DataBase Reference: N-(4-(trifluoromethyl)phenyl)benzothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(trifluoromethyl)phenyl)benzothioamide(343617-78-7)
• EPA Substance Registry System: N-(4-(trifluoromethyl)phenyl)benzothioamide(343617-78-7)

Safety Data

• Hazardous Substances Data: 343617-78-7(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 455-14-1 4-trifluoromethylphenylamine 
• 150-60-7 dibenzyl disulphide 
• 350-98-1 N-(4-(trifluoromethyl)phenyl)benzamide 

Relevant articles and documents

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.

Exogenous Photosensitizer-, Metal-, and Base-Free Visible-Light-Promoted C-H Thiolation via Reverse Hydrogen Atom Transfer

Visible-light-driven, intramolecular C(sp2)-H thiolation has been achieved without addition of a photosensitizer, metal catalyst, or base. This reaction induces the cyclization of thiobenzanilides to benzothiazoles. The substrate absorbs visible light, and its excited state undergoes a reverse hydrogen-atom transfer (RHAT) with 2,2,6,6-tetramethylpiperidine N-oxyl to form a sulfur radical. The addition of the sulfur radical to the benzene ring gives an aryl radical, which then rearomatizes to benzothiazole via RHAT.

A process for preparing thio amide of the new method (by machine translation)

The invention discloses a thio amide preparation method, the method to non-metal catalyst substance iodide as a catalyst, in order to disulfide and amine compound as a reaction substrate in the organic solvent, 20 - 140 °C effective reaction, in the 5 - 20 h of time, can be efficient, easily to obtain the thio amide compound. This method has the advantages of low cost, high yield, simple and convenient operation, no pollution and the like, for the realization of its industrial production has certain feasibility. (by machine translation)

Organocatalytic syntheses of benzoxazoles and benzothiazoles using aryl iodide and oxone via C-H functionalization and C-O/S bond formation

An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo-4-nitrobenzene as catalyst and oxone as an inexpensive and environmentally safe terminal oxidant at room temperature in air via oxidative C-H functionalization and C-O/S bond formation. The procedure is simple and general and provides an effective route for the construction of functionalized 2-alkyl-/arylbenzoxazoles and 2-alkyl-/arylbenzothiazoles with moderate to high yields. The synthetic and mechanistic aspects have been described.