34374-22-6

Basic information

• Product Name: N-[(3-chloro-8-methoxy-11H-indolo[3,2-c]quinolin-9-yl)methyl]-N-ethylethanamine
• Synonyms: 3-Chloro-8-methoxy-9-diethylaminomethyl-11H-indolo[3,2-c]quinoline
• CAS NO: 34374-22-6
• Molecular Formula: C₂₁H₂₂ClN₃O
• Molecular Weight: 367.8719
• Mol File: 34374-22-6.mol

Chemical Properties

• Boiling Point: 549°C at 760 mmHg
• Flash Point: 285.8°C
• Density: 1.273g/cm³
• Vapor Pressure: 4.21E-12mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: N-[(3-chloro-8-methoxy-11H-indolo[3,2-c]quinolin-9-yl)methyl]-N-ethylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3-chloro-8-methoxy-11H-indolo[3,2-c]quinolin-9-yl)methyl]-N-ethylethanamine(34374-22-6)
• EPA Substance Registry System: N-[(3-chloro-8-methoxy-11H-indolo[3,2-c]quinolin-9-yl)methyl]-N-ethylethanamine(34374-22-6)

Safety Data

• Hazardous Substances Data: 34374-22-6(Hazardous Substances Data)

Upstream product

• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 
• 108-42-9 3-chloro-aniline 
• 155250-02-5 methyl N-(3-chlorophenyl)-N-<(4-methylphenyl)sulfonyl>-β-alaninate 
• 66737-56-2 N-(3-chlorophenyl)-N-<(4-methylphenyl)sulfonyl>-β-alanine 
• 66820-85-7 7-chloro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one 
• 42313-47-3 methyl N-(3-chlorophenyl)-β-alaninate 

Relevant articles and documents

Structure-activity relationships of antimalarial indoloquinolines

Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents