66737-56-2

Upstream product

• 108-42-9 3-chloro-aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 79-10-7 acrylic acid 
• 42313-47-3 methyl N-(3-chlorophenyl)-β-alaninate 
• 155250-02-5 methyl N-(3-chlorophenyl)-N-<(4-methylphenyl)sulfonyl>-β-alaninate 

Downstream Products

• 66820-85-7 7-chloro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one 
• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 
• 116792-06-4 3-chloro-8-methoxy-11H-indolo<3,2-c>quinoline 
• 34374-22-6 NSC 317605 
• 155249-55-1 3-Chloro-11-phenyl-11H-indolo[3,2-c]quinoline 
• 21617-16-3 5-chloro-2,3-dihydro-4(1H)-quinolinone 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

Structure-activity relationships of antimalarial indoloquinolines

Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents