343788-67-0

Basic information

• Product Name: 1-Boc-4-methylpiperidine-4-carboxamide
• Synonyms: 1-Boc-4-methylpiperidine-4-carboxamide;tert-butyl 4-carbaMoyl-4-Methylpiperidine-1-carboxylate;4-Carbamoyl-4-methyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-4-methyl-, 1,1-dimethylethyl ester;N-Boc-4-methylpiperidine-4-benzamide
• CAS NO: 343788-67-0
• Molecular Formula: C₁₂H₂₂N₂O₃
• Molecular Weight: 242.317
• Mol File: 343788-67-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 383.6°C at 760 mmHg
• Flash Point: 185.8°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 4.35E-06mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.40±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-4-methylpiperidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-methylpiperidine-4-carboxamide(343788-67-0)
• EPA Substance Registry System: 1-Boc-4-methylpiperidine-4-carboxamide(343788-67-0)

Safety Data

• Hazardous Substances Data: 343788-67-0(Hazardous Substances Data)

Usage

General Description

1-Boc-4-methylpiperidine-4-carboxamide, also known as N-tert-butoxycarbonyl-4-methylpiperidine-4-carboxamide, is a chemical compound with the molecular formula C13H23N3O2. It is a derivative of piperidine and is commonly used as a building block in organic synthesis. 1-Boc-4-methylpiperidine-4-carboxamide is often utilized as a protecting group for amines, as the Boc (tert-butoxycarbonyl) group can be easily removed under mild conditions, allowing for the selective modification of other functional groups in a molecule. It is also used in the pharmaceutical industry for the synthesis of various drugs and potential drug candidates. 1-Boc-4-methylpiperidine-4-carboxamide is a versatile and important chemical intermediate with various applications in organic chemistry and drug development.

InChI:InChI=1/C12H22N2O3/c1-11(2,3)17-10(16)14-7-5-12(4,6-8-14)9(13)15/h5-8H2,1-4H3,(H2,13,15)

Upstream product

• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 189321-63-9 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid 
• 530115-96-9 4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 189442-87-3 ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate 

Downstream Products

• 1195748-58-3 4-methylpiperidine-4-carboxamide 4-methylbenzenesulfonate 
• 951745-01-0 4-methyl-4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester 
• 1037792-97-4 4-[4-(4-methanesulfonylphenoxymethyl)thiazol-2-yl]-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 1383793-10-9 methyl 2-[4-({[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]carbonyl}amino)benzyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxylate 
• 948894-26-6 4-methylpiperidine-4-carbonitrile hydrochloride 
• 1257301-28-2 4-methylpiperidine-4-carboxamide hydrochloride 
• 530115-96-9 4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 236406-22-7 tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate 
• 933694-51-0 (1,4-dimethylpiperidin-4-yl)methanamine 

Relevant articles and documents

OXYMETHYLENE ARYL COMPOUNDS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES OR GASTROINTESTINAL CONDITIONS

Use of oxymethylene aryl GPRl 19 agonists, and optionally DPP IV inhibitors and optionally metformin, for the treatment of inflammatory gastrointestinal diseases or gastrointestinal conditions involving malabsorption of nutrients and/or fluids are provide

PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDACl and/or HDAC2 activity.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein R1, R2, X, p, q, m, n, and Ring C have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.