34392-85-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2-chloro-6-methoxypyridin-3-amine is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of diverse drug molecules, contributing to the development of new treatments for a range of medical conditions.
Used in Agrochemical Production:
In the agrochemical industry, 2-chloro-6-methoxypyridin-3-amine serves as a crucial component in the formulation of pesticides and other crop protection agents. Its incorporation enhances the effectiveness of these products, supporting agricultural productivity and crop health.
Used in Organic Chemistry as a Building Block:
2-chloro-6-methoxypyridin-3-amine is employed as a versatile building block in organic chemistry. Its functional groups facilitate the synthesis of a wide array of complex organic molecules, expanding the scope of chemical research and innovation.
Used in Medicinal Chemistry for Drug Discovery:
2-chloro-6-methoxypyridin-3-amine is leveraged in medicinal chemistry as a starting material for drug discovery. Its biological activity makes it a promising candidate for the development of novel therapeutics, potentially leading to breakthroughs in the treatment of various diseases and conditions.

InChI:InChI=1/C7H7ClN2O/c1-4(11)6-3-2-5(9)7(8)10-6/h2-3H,9H2,1H3

Upstream product

• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 

Downstream Products

• 952059-64-2 6-methoxy-1,7-naphthyridin-4(1H)-one 
• 952059-61-9 4-chloro-6-methoxy-1,7-naphthyridine 
• 27017-64-7 6-methoxy-1,5-naphthyridin-2(1H)-one 
• 1352997-83-1 methyl 2-(8-(2-chloro-6-methoxypyridin-3-ylamino)octyl)-6-methoxybenzoate 
• 83732-68-7 2,3-dichloro-6-methoxypyridine 

Relevant academic research and scientific papers

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol

A metal-free reduction of aromatic nitro compounds to the corresponding amines has been achieved by a combination of B2pin2 and KOtBu in isopropanol. A series of nitro compounds containing various reducible functional groups were chemoselectively reduced in good to excellent yields.

Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides

Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

9-Azabicyclo[3.3.1]nonane derivatives

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.

BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands, for receptor localization studies.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.