952059-64-2

Upstream product

• 34392-85-3 3-amino-2-chloro-6-methoxypyridine 
• 952059-62-0 5-[[(2-chloro-6-methoxypyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 952059-63-1 8-chloro-6-methoxy-1H-1,7-naphthyridin-4-one 
• 1018812-95-7 tert-butyl N-(4-acetyl-6-methoxypyridin-3-yl)carbamate 
• 183741-80-2 tert-butyl N-(6-methoxypyridin-3-yl)carbamate 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 

Downstream Products

• 952059-61-9 4-chloro-6-methoxy-1,7-naphthyridine 
• 1431985-23-7 C₂₃H₂₄F₂N₆O₂ 
• 1431985-54-4 6-methoxy-1,7-naphthyridin-4(1H)-one 
• 1431985-53-3 6-methoxy-1,7-naphthyridin-4(1H)-one 

Relevant academic research and scientific papers

Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway provides a promising new approach for cancer therapy. Through a rational design, a novel series of thienopyrimidine was discovered as highly pote

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.